Skip to main content
Top
Published in: Journal of Gastrointestinal Cancer 3/2019

01-09-2019 | Case Report

Metachronous Hepatic Angiosarcoma Presenting as a Mimic of Recurrent Hepatocellular Carcinoma

Authors: Eric K. C. Lau, Bernette Tsai, Harry Morrison, Michael Deftos, Albert Y. Lin

Published in: Journal of Gastrointestinal Cancer | Issue 3/2019

Login to get access

Excerpt

Primary hepatic angiosarcoma (PHA) is the third most common primary liver malignancy, after hepatocellular carcinoma and cholangiocarcinoma, accounting for 2% of primary liver malignancies and less than 1% of all sarcomas [1, 2]. PHA has been known to present in men over 60 years of age and has been associated with neurofibromatosis-1, anabolic steroids, hemochromatosis, vinyl chloride, thorotrast radiocontrast, and arsenic, although most cases are idiopathic [2, 3]. PHA is a very aggressive malignancy with a historical median survival of only 5 months despite treatment [4]. Our case highlights how this deadly disease can present as a mimic of recurrent hepatocellular carcinoma (HCC) in a patient with known prior HCC. …
Literature
2.
go back to reference Huang NC, Kuo YC, Chiang JC, Hung SY, Wang HM, Hung YM, et al. Hepatic angiosarcoma may have fair survival nowadays. Medicine (Baltimore). 2015;94(19):e816.CrossRef Huang NC, Kuo YC, Chiang JC, Hung SY, Wang HM, Hung YM, et al. Hepatic angiosarcoma may have fair survival nowadays. Medicine (Baltimore). 2015;94(19):e816.CrossRef
3.
go back to reference Kim HR, Rha SY, Cheon SH, Roh JK, Park YN, Yoo NC. Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma. Ann Oncol. 2009;20(4):780–7.CrossRefPubMed Kim HR, Rha SY, Cheon SH, Roh JK, Park YN, Yoo NC. Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma. Ann Oncol. 2009;20(4):780–7.CrossRefPubMed
4.
go back to reference Zheng YW, Zhang XW, Zhang JL, Hui ZZ, du WJ, Li RM, et al. Primary hepatic angiosarcoma and potential treatment options. J Gastroenterol Hepatol. 2014;29(5):906–11.CrossRefPubMed Zheng YW, Zhang XW, Zhang JL, Hui ZZ, du WJ, Li RM, et al. Primary hepatic angiosarcoma and potential treatment options. J Gastroenterol Hepatol. 2014;29(5):906–11.CrossRefPubMed
5.
go back to reference Koyama T, Fletcher JG, Johnson CD, Kuo MS, Notohara K, Burgart LJ. Primary hepatic angiosarcoma: findings at CT and MRI. Radiology. 2002;222(3):667–73.CrossRefPubMed Koyama T, Fletcher JG, Johnson CD, Kuo MS, Notohara K, Burgart LJ. Primary hepatic angiosarcoma: findings at CT and MRI. Radiology. 2002;222(3):667–73.CrossRefPubMed
6.
go back to reference Choi JY, Lee JM, Sirlin CB. CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part II. Extracellular agents, hepatobiliary agents, and ancillary imaging features. Radiology. 2014;273(1):30–50.CrossRefPubMedPubMedCentral Choi JY, Lee JM, Sirlin CB. CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part II. Extracellular agents, hepatobiliary agents, and ancillary imaging features. Radiology. 2014;273(1):30–50.CrossRefPubMedPubMedCentral
7.
go back to reference Park YS, Kim JH, Kim KW, Lee IS, Yoon HK, Ko GY, et al. Primary hepatic angiosarcoma: imaging findings and palliative treatment with transcatheter arterial chemoembolization or embolization. Clin Radiol. 2009;64(8):779–85.CrossRefPubMed Park YS, Kim JH, Kim KW, Lee IS, Yoon HK, Ko GY, et al. Primary hepatic angiosarcoma: imaging findings and palliative treatment with transcatheter arterial chemoembolization or embolization. Clin Radiol. 2009;64(8):779–85.CrossRefPubMed
8.
go back to reference Rao P, Lahat G, Arnold C, Gavino AC, Lahat S, Hornick JL, et al. Angiosarcoma: a tissue microarray study with diagnostic implications. Am J Dermatopathol. 2013;35(4):432–7.CrossRefPubMed Rao P, Lahat G, Arnold C, Gavino AC, Lahat S, Hornick JL, et al. Angiosarcoma: a tissue microarray study with diagnostic implications. Am J Dermatopathol. 2013;35(4):432–7.CrossRefPubMed
9.
go back to reference Folpe AL, Chand EM, Goldblum JR, Weiss SW. Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. Am J Surg Pathol. 2001;25(8):1061–6.CrossRefPubMed Folpe AL, Chand EM, Goldblum JR, Weiss SW. Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. Am J Surg Pathol. 2001;25(8):1061–6.CrossRefPubMed
10.
go back to reference Ordóñez NG. Immunohistochemical endothelial markers: a review. Adv Anat Pathol. 2012;19(5):281–95.CrossRefPubMed Ordóñez NG. Immunohistochemical endothelial markers: a review. Adv Anat Pathol. 2012;19(5):281–95.CrossRefPubMed
11.
go back to reference Bioulac-Sage P, Laumonier H, Laurent C, Blanc J, Balabaud C. Benign and malignant vascular tumors of the liver in adults. Semin Liver Dis. 2008;28(3):302–14.CrossRefPubMed Bioulac-Sage P, Laumonier H, Laurent C, Blanc J, Balabaud C. Benign and malignant vascular tumors of the liver in adults. Semin Liver Dis. 2008;28(3):302–14.CrossRefPubMed
12.
go back to reference Weitz J, Klimstra DS, Cymes K, Jarnagin WR, D'Angelica M, la Quaglia MP, et al. Management of primary liver sarcomas. Cancer. 2007;109(7):1391–6.CrossRefPubMed Weitz J, Klimstra DS, Cymes K, Jarnagin WR, D'Angelica M, la Quaglia MP, et al. Management of primary liver sarcomas. Cancer. 2007;109(7):1391–6.CrossRefPubMed
13.
go back to reference Almogy G, Lieberman S, Gips M, Pappo O, Edden Y, Jurim O, et al. Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre. Eur J Surg Oncol. 2004;30(4):421–7.CrossRefPubMed Almogy G, Lieberman S, Gips M, Pappo O, Edden Y, Jurim O, et al. Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre. Eur J Surg Oncol. 2004;30(4):421–7.CrossRefPubMed
14.
go back to reference Agulnik M, Yarber JL, Okuno SH, von Mehren M, Jovanovic BD, Brockstein BE, et al. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol. 2013;24(1):257–63.CrossRef Agulnik M, Yarber JL, Okuno SH, von Mehren M, Jovanovic BD, Brockstein BE, et al. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol. 2013;24(1):257–63.CrossRef
15.
go back to reference Ray-Coquard I, Italiano A, Bompas E, le Cesne A, Robin YM, Chevreau C, et al. Sorafenib for patients with advanced angiosarcoma: a phase II trial from the French Sarcoma Group (GSF/GETO). Oncologist. 2012;17(2):260–6.CrossRefPubMedPubMedCentral Ray-Coquard I, Italiano A, Bompas E, le Cesne A, Robin YM, Chevreau C, et al. Sorafenib for patients with advanced angiosarcoma: a phase II trial from the French Sarcoma Group (GSF/GETO). Oncologist. 2012;17(2):260–6.CrossRefPubMedPubMedCentral
16.
go back to reference Kojiro M, Kawano Y, Kawasaki H, Nakashima T, Ikezaki H. Thorotrast-induced hepatic angiosarcoma, and combined hepatocellular and cholangiocarcinoma in a single patient. Cancer. 1982;49(10):2161–4.CrossRefPubMed Kojiro M, Kawano Y, Kawasaki H, Nakashima T, Ikezaki H. Thorotrast-induced hepatic angiosarcoma, and combined hepatocellular and cholangiocarcinoma in a single patient. Cancer. 1982;49(10):2161–4.CrossRefPubMed
17.
go back to reference Athanasopoulos PG, Hadjittofi C, Luong TV, O’Beirne J, Sharma D. Synchronous hepatic epithelioid hemangioendothelioma and hepatocellular carcinoma: first case report in the literature and challenges. Medicine (Baltimore). 2015;94(34):e1377.CrossRef Athanasopoulos PG, Hadjittofi C, Luong TV, O’Beirne J, Sharma D. Synchronous hepatic epithelioid hemangioendothelioma and hepatocellular carcinoma: first case report in the literature and challenges. Medicine (Baltimore). 2015;94(34):e1377.CrossRef
18.
go back to reference Shah BK, Kandel P, Khanal A, et al. Second primary malignancies in hepatocellular cancer—a US population-based study. Anticancer Res. 2016;36(7):3511–4.PubMed Shah BK, Kandel P, Khanal A, et al. Second primary malignancies in hepatocellular cancer—a US population-based study. Anticancer Res. 2016;36(7):3511–4.PubMed
19.
go back to reference Nzeako UC, Goodman ZD, Ishak KG. Association of hepatocellular carcinoma in north American patients with extrahepatic primary malignancies. Cancer. 1994;74(10):2765–71.CrossRefPubMed Nzeako UC, Goodman ZD, Ishak KG. Association of hepatocellular carcinoma in north American patients with extrahepatic primary malignancies. Cancer. 1994;74(10):2765–71.CrossRefPubMed
Metadata
Title
Metachronous Hepatic Angiosarcoma Presenting as a Mimic of Recurrent Hepatocellular Carcinoma
Authors
Eric K. C. Lau
Bernette Tsai
Harry Morrison
Michael Deftos
Albert Y. Lin
Publication date
01-09-2019
Publisher
Springer US
Published in
Journal of Gastrointestinal Cancer / Issue 3/2019
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-018-0094-3

Other articles of this Issue 3/2019

Journal of Gastrointestinal Cancer 3/2019 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.