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BMC Nephrology
Published in: BMC Nephrology 1/2014

Open Access 01-12-2014 | Review

Metabolic acidosis and the progression of chronic kidney disease

Authors: Wei Chen, Matthew K Abramowitz

Published in: BMC Nephrology | Issue 1/2014

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Abstract

Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the treatment of acidosis with oral alkali can slow the progression of kidney disease.
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Metadata
Title
Metabolic acidosis and the progression of chronic kidney disease
Authors
Wei Chen
Matthew K Abramowitz
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2014
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/1471-2369-15-55

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