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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2014

Open Access 01-12-2014 | Research

Meta-analyses between 18 candidate genetic markers and overweight/obesity

Authors: Linlin Tang, Huadan Ye, Qingxiao Hong, Fei Chen, Qinwen Wang, Leiting Xu, Shizhong Bu, Qiong Liu, Meng Ye, Dao Wen Wang, Yifeng Mai, Shiwei Duan

Published in: Diagnostic Pathology | Issue 1/2014

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Abstract

Aims

The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity.

Methods

A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0.

Results

Our results showed that SH2B1 rs7498665 polymorphism was significantly associated with the risk of overweight/obesity (overall odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.09-1.34, P = 0.0004). Increased risk of overweight/obesity was also observed in FAIM2 rs7138803 polymorphism (overall OR = 1.11, 95% CI = 1.01-1.22, P = 0.04).

Conclusion

Our meta-analyses have shown the important role of 2 polymorphisms (SH2B1 rs7498665 and FAIM2 rs7138803) in the development of overweight/obesity. This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity.

Virtual slides

The virtual slide(s) for this article can be found here: http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​2785487401176182​.
Appendix
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Metadata
Title
Meta-analyses between 18 candidate genetic markers and overweight/obesity
Authors
Linlin Tang
Huadan Ye
Qingxiao Hong
Fei Chen
Qinwen Wang
Leiting Xu
Shizhong Bu
Qiong Liu
Meng Ye
Dao Wen Wang
Yifeng Mai
Shiwei Duan
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-9-56

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