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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2014

Open Access 01-12-2014 | Case Report

Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: a case report with immunohistochemical and molecular study

Authors: Fabiana Tatangelo, Monica Cantile, Alessia Pelella, Nunzia Simona Losito, Giosuè Scognamiglio, Franco Bianco, Andrea Belli, Gerardo Botti

Published in: Diagnostic Pathology | Issue 1/2014

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Abstract

Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign.
Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.
We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.

Virtual slides

The virtual slides for this article can be found here: http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​3720959161096807​
Appendix
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Metadata
Title
Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: a case report with immunohistochemical and molecular study
Authors
Fabiana Tatangelo
Monica Cantile
Alessia Pelella
Nunzia Simona Losito
Giosuè Scognamiglio
Franco Bianco
Andrea Belli
Gerardo Botti
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-9-54

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