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BMC Immunology
Published in: BMC Immunology 1/2015

Open Access 01-12-2015 | Review

Mesenchymal stromal cells to modulate immune reconstitution early post-hematopoietic cell transplantation

Authors: Elizabeth O. Stenger, Lakshmanan Krishnamurti, Jacques Galipeau

Published in: BMC Immunology | Issue 1/2015

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Abstract

Mesenchymal stromal cells (MSCs) are multipotent progenitor cells known to modulate the immune system and to promote hematopoiesis. These dual effects make MSCs attractive for use as cellular therapy in hematopoietic cell transplantation (HCT). MSCs can be used peri-HCT or pre-engraftment to modulate immune reconstitution, promoting hematopoietic stem cell (HSC) engraftment and/or preventing graft-versus-host disease (GVHD). Pre-clinical studies have demonstrated that MSCs can potentiate HSC engraftment and prevent GVHD in a variety of animal models. Clinical trials have been small and largely non-randomized but have established safety and early evidence of efficacy, supporting the need for larger randomized trials.
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Metadata
Title
Mesenchymal stromal cells to modulate immune reconstitution early post-hematopoietic cell transplantation
Authors
Elizabeth O. Stenger
Lakshmanan Krishnamurti
Jacques Galipeau
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Immunology / Issue 1/2015
Electronic ISSN: 1471-2172
DOI
https://doi.org/10.1186/s12865-015-0135-7

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