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01-10-2017 | Review Article

Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease

Authors: Zhu Li-na, Chen Deng, Xu Da, Chen Si-han, Wang Hai-jiao, Liu Ling

Published in: Neurological Sciences | Issue 10/2017

Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a member of the novel evolutionary conserved neurotrophic factor (NTF) family. MANF has a unique structure and an unparalleled dual mode of action that differs from other known NTFs. Recent studies have shown that MANF protects cells from endoplasmic reticulum stress. In addition, an increasing number of studies have found MANF plays an important role in nervous system disease. This review focuses on MANF, summarizing its unique structure, potential signaling pathway, and role in neurological disease.

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Title: Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease
Authors: Zhu Li-na
Chen Deng
Xu Da
Chen Si-han
Wang Hai-jiao
Liu Ling
Publication date: 01-10-2017
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 10/2017
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-017-3042-2

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Springer Medicine

Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease

Abstract

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Springer Medicine

Abstract

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