Top

Published in:

01-10-2017 | Original Article

Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in NMOSD

Authors: Jie Lin, Binbin Xue, Jia Li, Huaqing Xu, Xiaming Huang, Zhichao Yao, Xiang Li, Junhui Xia

Published in: Neurological Sciences | Issue 10/2017

Abstract

Neutrophil to lymphocyte ratio (NLR) was introduced to assess the activity in autoimmune diseases. Neuromyelitis optica spectrum disorder (NMOSD) has been defined as a chronic inflammatory disease with a course of relapse-remission. Therefore, the relationship between NLR and NMOSD was assessed in this article. Data of NMOSD patients was extracted. NLR is calculated as the absolute count of neutrophil divided by the absolute count of lymphocytes. Correlations between NLR and characteristics of NMOSD patients were evaluated. Effect of treatments on NLR was also analyzed. Increased level of NLR was observed in patients with NMOSD compared healthy individuals (p < 0.001); moreover, patients who were experiencing acute attack had a higher level of NLR compared with those who in remission (p < 0.001). NLR was correlated with RDW (r = 0.288, p = 0.021), ΔEDSS (r = 0.301, p = 0.016). NLR may be a helpful marker to assess the disease activity of NMOSD. Meanwhile, NLR may reflect the aggravated degree of neurological disability.

Matiello M, Jacob A, Wingerchuk DM, Weinshenker BG (2007) Neuromyelitis optica. Curr Opin Neurol 20:255–260CrossRefPubMed

Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T et al (2015) International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 85:177–189CrossRefPubMedPubMedCentral

Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K et al (2004) A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 364:2106–2112CrossRefPubMed

Uzawa A, Mori M, Sawai S, Masuda S, Muto M, Uchida T et al (2013) Cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels are increased during initial neuromyelitis optica attacks. Clin Chim Acta 421:181–183CrossRefPubMed

Ishizu T, Osoegawa M, Mei FJ, Kikuchi H, Tanaka M, Takakura Y et al (2005) Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 128:988–1002CrossRefPubMed

Wojkowska DW, Szpakowski P, Ksiazek-Winiarek D, Leszczynski M, Glabinski A (2014) Interactions between neutrophils, Th17 cells, and chemokines during the initiation of experimental model of multiple sclerosis. Mediat Inflamm 2014:590409CrossRef

Lin J, Li X, Xia J (2016) Th17 cells in neuromyelitis optica spectrum disorder: a review. Int J Neurosci:1–10

Núñez J, Núñez E, Bodí V, Sanchis J, Miñana G, Mainar L et al (2008) Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol 101:747–752CrossRefPubMed

Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G et al (2007) Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J 154:995–1002CrossRefPubMed

10.

Demirci S, Demirci S, Kutluhan S, Koyuncuoglu HR, Yurekli VA (2016) The clinical significance of the neutrophil-to-lymphocyte ratio in multiple sclerosis. Int J Neurosci 126:700–706PubMed

11.

Wu Y, Chen Y, Yang X, Chen L, Yang Y (2016) Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus. Int Immunopharmacol 36:94–99CrossRefPubMed

12.

Rifaioglu EN, Bülbül ŞB, Ekiz Ö, Cigdem DA (2014) Neutrophil to lymphocyte ratio in Behçet’s disease as a marker of disease activity. Acta Dermatovenerol Alp Pannonica Adriat 23:65–67PubMed

13.

Hu ZD, Sun Y, Guo J, Huang YL, Qin BD, Gao Q et al (2014) Red blood cell distribution width and neutrophil/lymphocyte ratio are positively correlated with disease activity in primary Sjögren's syndrome. Clin Biochem 47:287–290CrossRefPubMed

14.

Celikbilek M, Dogan S, Ozbakır Z, Kücük H, Gürsoy S et al (2013) Neutrophil-lymphocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 27:72–76CrossRefPubMed

15.

Conteduca V, Crabb SJ, Jones RJ, Caffo O, Elliott T, Scarpi E et al (2016) Persistent neutrophil to lymphocyte ratio >3 during treatment with enzalutamide and clinical outcome in patients with castration-resistant prostate cancer. PLoS One 11:e0158952CrossRefPubMedPubMedCentral

16.

Kasuga J, Kawahara T, Takamoto D, Fukui S, Tokita T, Tadenuma T et al (2016) Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer. BMC Cancer 16:396CrossRefPubMedPubMedCentral

17.

Kim BJ, Cho SH, Cho KI, Kim HS, Heo JH, Cha TJ (2016) The combined impact of neutrophil-to-lymphocyte ratio and type 2 diabetic mellitus on significant coronary artery disease and carotid artery atherosclerosis. J Cardiovasc Ultrasound 24:115–122CrossRefPubMedPubMedCentral

18.

Karakas MS, Korucuk N, Tosun V, Altekin RE, Koç F, Ozbek SC et al (2016) Red cell distribution width and neutrophil-to-lymphocyte ratio predict left ventricular dysfunction in acute anterior ST-segment elevation myocardial infarction. J Saudi Heart Assoc 28:152–158CrossRefPubMed

19.

Park CH, Han DS, Jeong JY, Eun CS, Yoo KS, Jeon YC et al (2016) The optimal cut-off value of neutrophil-to-lymphocyte ratio for predicting prognosis in adult patients with Henoch-Schönlein purpura. PLoS One 11:e0153238CrossRefPubMedPubMedCentral

20.

Nalbant A, Cinemre H, Kaya T, Varim C, Varim P, Tamer A (2016) Neutrophil to lymphocyte ratio might help prediction of acute myocardial infarction in patients with elevated serum creatinine. Pak J Med Sci 32:106–110PubMedPubMedCentral

21.

Yang HJ, Guo Z, Yang YT, Jiang JH, Qi YP, Li JJ et al (2016) Blood neutrophil-lymphocyte ratio predicts survival after hepatectomy for hepatocellular carcinoma: a propensity score-based analysis. World J Gastroenterol 22:5088–5095CrossRefPubMedPubMedCentral

22.

Ho CL, Lu CS, Chen JH, Chen YG, Huang TC, Wu YY (2015) Neutrophil/Lymphocyte Ratio, Lymphocyte/Monocyte Ratio, and Absolute Lymphocyte Count/Absolute Monocyte Count Prognostic Score in Diffuse Large B-Cell Lymphoma: Useful Prognostic Tools in the Rituximab Era. Medicine (Baltimore) 94:e993CrossRef

23.

Kedziora-Kornatowska KZ (1999) Production of superoxide and nitric oxide by granulocytes in non-insulin-dependent diabetic patients with and without diabetic nephropathy. IUBMB Life 48:359–362CrossRefPubMed

24.

Peng YF, Cao WY, Zhang Q, Chen D, Zhang ZX (2015) Assessment of the Relationship Between Red Cell Distribution Width and Multiple Sclerosis. Medicine (Baltimore) 94:e1182CrossRef

25.

Vayá A, Alis R, Hernández JL, Calvo J, Micó L, Romagnoli M et al (2013) RDW in patients with systemic lupus erythematosus. Influence of anaemia and inflammatory markers. Clin Hemorheol Microcirc 54:333–339PubMed

26.

Rodríguez-Carrio J, Alperi-López M, López P, Alonso-Castro S, Carro-Esteban SR, Ballina-García FJ et al (2015) Red cell distribution width is associated with endothelial progenitor cell depletion and vascular-related mediators in rheumatoid arthritis. Atherosclerosis 240:131–136CrossRefPubMed

27.

Linhares UC, Schiavoni PB, Barros PO, Kasahara TM, Teixeira B, Ferreira TB et al (2013) The ex vivo production of IL-6 and IL-21 by CD4+ T cells is directly associated with neurological disability in neuromyelitis optica patients. J Clin Immunol 33:179–189CrossRefPubMed

28.

Cabre P, González-Quevedo A, Bonnan M, Saiz A, Olindo S, Graus F et al (2009) Relapsing neuromyelitis optica: long term history and clinical predictors of death. J Neurol Neurosurg Psychiatry 80:1162–1164CrossRefPubMed

29.

Wingerchuk DM, Weinshenker BG (2003) Neuromyelitis optica: clinical predictors of a relapsing course and survival. Neurology 60:848–853CrossRefPubMed

30.

Jarius S, Frederikson J, Waters P, Paul F, Akman-Demir G, Marignier R et al (2010) Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. J Neurol Sci 298:158–162CrossRefPubMed

31.

Kitley J, Woodhall M, Waters P, Leite MI, Devenney E, Craig J et al (2012) Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype. Neurology 79:1273–1277CrossRefPubMed

32.

Argyriou AA, Makris N (2008) Neuromyelitis optica: a distinct demyelinating disease of the central nervous system. Acta Neurol Scand 118:209–217CrossRefPubMed

33.

Kira J (2011) Neuromyelitis optica and opticospinal multiple sclerosis: mechanisms and pathogenesis. Pathophysiology 18:69–79CrossRefPubMed

Title: Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in NMOSD
Authors: Jie Lin
Binbin Xue
Jia Li
Huaqing Xu
Xiaming Huang
Zhichao Yao
Xiang Li
Junhui Xia
Publication date: 01-10-2017
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 10/2017
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-017-3068-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in NMOSD

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 10/2017

Determinants of botulinum toxin discontinuation in multiple sclerosis: a retrospective study

Serum methylmalonic acid correlates with neuropathic pain in idiopathic Parkinson’s disease

Tarsal tunnel syndrome: still more opinions than evidence. Status of the art

Central conduction abnormalities in patients receiving levodopa-carbidopa intestinal gel infusion

Dramatic improvement of impulsive aggressive behaviour following shunt surgery in a patient with idiopathic normal pressure hydrocephalus

Tapentadol in neuropathic pain cancer patients: a prospective open label study