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Critical Care
Published in: Critical Care 1/2015

01-12-2015 | Letter

Meropenem therapy in extracorporeal membrane oxygenation patients: an ongoing pharmacokinetic challenge

Authors: Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Published in: Critical Care | Issue 1/2015

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Excerpt

We agree with the recent commentary of Gonçalves-Pereira and Oliveira refuting a ‘one size fits all’ paradigm of antibiotic dosing in patients subjected to extracorporeal circulation [1] but want to focus somewhat further on meropenem pharmacokinetics (PK). …
Literature
1.
2.
Taccone FS, Laterre PF, Dugernier T, Spapen H, Delattre I, Witebolle X, et al. Insufficient β- lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care. 2010;14:R126.CrossRefPubMedPubMedCentral
3.
Roberts JA, Kirkpatrick CM, Roberts MS, Robertson TA, Dalley AJ, Lipman J. Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. J Antimicrob Chemother. 2009;64:142–50.CrossRefPubMed
4.
Honore PM, Jacobs R, Spapen HD. Antimicrobial dosing during extracorporeal membrane oxygenation. In: Vincent JL, editor. Annual update on intensive care and emergency care. Cham: Springer International Publishing; 2014. p. 43–53.
5.
Gonçalves-Pereira J, Paiva JA. Dose modulation: a new concept of antibiotic therapy in the critically ill patient ? J Crit Care. 2013;28:341–6.CrossRefPubMed
Metadata
Title
Meropenem therapy in extracorporeal membrane oxygenation patients: an ongoing pharmacokinetic challenge
Authors
Patrick M. Honore
Rita Jacobs
Inne Hendrickx
Elisabeth De Waele
Viola Van Gorp
Herbert D. Spapen
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-0953-2

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