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Critical Care
Published in: Critical Care 6/2014

Open Access 01-12-2014 | Commentary

Antibiotics and extracorporeal circulation – one size does not fit all

Authors: João Gonçalves-Pereira, Bruno Oliveira

Published in: Critical Care | Issue 6/2014

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Abstract

Dosing of antibiotics in critically ill patients is a significant challenge. The increasing number of patients undergoing extracorporeal membrane oxygenation further complicates the issue due to inflammatory activation and to drug sequestration in the circuit. Since patients receiving extracorporeal membrane oxygenation commonly face severe infections, appropriate antibiotic selection and correct dosing is of paramount importance to improve survival. Therapeutic drug monitoring (whenever available) or population pharmacokinetics, based on readily available clinical and laboratory data, should help tailor antibiotic dosing to the individual patient.
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Metadata
Title
Antibiotics and extracorporeal circulation – one size does not fit all
Authors
João Gonçalves-Pereira
Bruno Oliveira
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-014-0695-6

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