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European Journal of Clinical Microbiology & Infectious Diseases

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01-07-2021 | Meningitis | Brief Report

The yield of CSF molecular testing in febrile neonates

Authors: Basheer Nassrallah, Ellen Bamberger, Sarah Cohen, Isaac Srugo, Orit Golan-Shany, Yulia Shlonsky, Raeda Mubariki, Jacob Genizi

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 7/2021

Abstract

We retrospectively examined the yield of a cerebrospinal fluid (CSF) multiplex real-time PCR assay of febrile young infants undergoing a full sepsis work-up. Eighty infants were included in the study: Forty-nine (61%) neonates and 31 (39%) 29–90 day-old patients were included in the study. A viral pathogen was detected in 59% (47/80) of the samples, human enterovirus in 53% (42/80) and Human parechovirus in 6% (5/80). The CSF of nearly half of the subjects with CNS infection was without pleocytosis; all CSF cultures were negative. Multiplex PCR CSF testing enhances the diagnosis of pathogen-specific viral CNS infection among febrile young infants.

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Title: The yield of CSF molecular testing in febrile neonates
Authors: Basheer Nassrallah
Ellen Bamberger
Sarah Cohen
Isaac Srugo
Orit Golan-Shany
Yulia Shlonsky
Raeda Mubariki
Jacob Genizi
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keywords: Meningitis
Polymerase Chain Reaction
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 7/2021
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-021-04168-8

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