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01-02-2021 | Meningioma | Original Article

High Mib-1-score correlates with new cranial nerve deficits after surgery for frontal skull base meningioma

Authors: Matthias Schneider, Valeri Borger, Ági Güresir, Albert Becker, Hartmut Vatter, Patrick Schuss, Erdem Güresir

Published in: Neurosurgical Review | Issue 1/2021

Abstract

Postoperative new cranial nerve deficits comprise severe concomitant morbidity in skull base meningioma surgery. Therefore, long-term cranial nerve integrity represents an important outcome measure. In the current study, we analyzed our institutional database in order to identify risk factors for postoperative new cranial nerve morbidity in the course of frontobasal meningioma surgery. Between 2009 and 2017, 195 patients were surgically treated for frontobasal meningioma at the authors’ institution. Postoperative cranial nerve function was assessed immediately after surgery as well as 12 months postoperatively. A univariate and multivariate analysis was performed to identify factors influencing favorable postoperative cranial nerve outcome. Tumors with histological Mib-1-labeling indices > 5% were associated with a significantly higher percentage of new cranial nerve deficits immediately after surgery compared with those with Mib-1-labeling indices ≤ 5% (39% versus 20%, p = 0.029). Elevated Mib-1-labeling indices could be correlated with high CD68-positive macrophage staining (54% for Mib-1 index > 5% versus 19% for Mib-1 index ≤ 5%, p = 0.001). Elevated Mib-1-labeling index correlates with initial new cranial nerve dysfunction after resection of frontal skull base meningioma. With regard to elevated CD68-positive macrophage staining in high Mib-1-positive meningiomas, initial postoperative new cranial nerve morbidity might partly reflect macrophage-based inflammatory immune responses.

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Title: High Mib-1-score correlates with new cranial nerve deficits after surgery for frontal skull base meningioma
Authors: Matthias Schneider
Valeri Borger
Ági Güresir
Albert Becker
Hartmut Vatter
Patrick Schuss
Erdem Güresir
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Meningioma
Meningioma
Published in: Neurosurgical Review / Issue 1/2021
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-019-01222-0

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Springer Medicine

High Mib-1-score correlates with new cranial nerve deficits after surgery for frontal skull base meningioma

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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