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01-02-2021 | Hydrocephalus | Original Article

Structural volumetry in NPH diagnostics and treatment—future or dead end?

Authors: Aleš Vlasák, Petr Skalický, Arnošt Mládek, Jiří Vrána, Vladimír Beneš, Ondřej Bradáč

Published in: Neurosurgical Review | Issue 1/2021

Abstract

To assess automated volumetric analysis as a potential presurgical diagnostic tool or as a method to potentially shed light on normal pressure hydrocephalus (NPH) pathophysiology. MRI imaging according to our protocol was performed in 29 NPH patients, 45 non-NPH (but suspected) patients and 15 controls. Twenty patients underwent a second MRI 3 months after ventriculoperitoneal (VP) shunt surgery. All structures relevant to NPH diagnosis were automatically segmented using commercial software. The results were subsequently tested using ANOVA analysis. Significant differences in the volumes of the corpus callosum, left hippocampus, internal globus pallidus, grey and white matter and ventricular volumes were observed between NPH group and healthy controls. However, the differences between NPH and non-NPH groups were non-significant. Three months after, VP shunt insertion decreased ventricular volume was the only clearly significant result (p value 0.0001). Even though a detailed volumetric study shows several significant differences, volumetric analysis as a standalone method does not provide a simple diagnostic biomarker, nor does it shed a light on an unknown NPH aetiology.

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Title: Structural volumetry in NPH diagnostics and treatment—future or dead end?
Authors: Aleš Vlasák
Petr Skalický
Arnošt Mládek
Jiří Vrána
Vladimír Beneš
Ondřej Bradáč
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Hydrocephalus
Hydrocephalus
Hydrocephalus
Published in: Neurosurgical Review / Issue 1/2021
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-020-01245-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Structural volumetry in NPH diagnostics and treatment—future or dead end?

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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