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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2018

Open Access 01-12-2018 | Letter to the Editor

Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Authors: Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen, Yangqiu Li

Published in: Journal of Hematology & Oncology | Issue 1/2018

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Abstract

Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM cells in the CD8+ population dramatically decreased together with increases in TEM and TEF cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in TSCM and TCM together with the increase in differentiated TEM and TEF subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients.
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Metadata
Title
Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
Authors
Ling Xu
Danlin Yao
Jiaxiong Tan
Zifan He
Zhi Yu
Jie Chen
Gengxin Luo
Chunli Wang
Fenfang Zhou
Xianfeng Zha
Shaohua Chen
Yangqiu Li
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2018
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-018-0636-y

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