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Open Access 01-06-2019 | Melanoma | Original Paper

Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds

Authors: Weicheng Wang, Yi Zhang, Souichi Nakashima, Seikou Nakamura, Tao Wang, Masayuki Yoshikawa, Hisashi Matsuda

Published in: Journal of Natural Medicines | Issue 3/2019

Abstract

The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 μM. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protein expression was observed, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition.

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Title: Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
Authors: Weicheng Wang
Yi Zhang
Souichi Nakashima
Seikou Nakamura
Tao Wang
Masayuki Yoshikawa
Hisashi Matsuda
Publication date: 01-06-2019
Publisher: Springer Singapore
Keywords: Melanoma
Melanoma
Theophylline
Published in: Journal of Natural Medicines / Issue 3/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-01276-2

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Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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