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01-06-2019 | Note

A new 2H-benzindazole compound from Alternaria alternata Shm-1, an endophytic fungus isolated from the fresh wild fruit of Phellinus igniarius

Authors: Xiuli Wu, Sa Wang, Cheng Liu, Caifang Zhang, Jinjing Guo, Xiaoya Shang

Published in: Journal of Natural Medicines | Issue 3/2019

Abstract

Endophytic fungi have been shown in recent years to produce a series of bioactive secondary metabolites. Several endophytic fungi were isolated from the fresh wild body of Phellinus igniarius, and initially evaluated for their antimicrobial activity. Among which, Shm-1 extract showed moderate inhibitory activity against Clavibacter michiganense and the fungus was identified to be Alternaria alternata Shm-1 through the comparison of morphological characteristics and the sequence of the rDNA ITS with those of other Alternaria species. A new 2H-benzindazole derivative, alterindazolin A (1), has been isolated from cultures of the endophyte Alternaria alternata Shm-1. Its structure was characterized as 1-benzyl-5-p-hydroxy-phenyloxygen-benz[e]indazole by spectroscopic data analysis including 1D NMR, 2D NMR and MS spectrum.

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Title: A new 2H-benzindazole compound from Alternaria alternata Shm-1, an endophytic fungus isolated from the fresh wild fruit of Phellinus igniarius
Authors: Xiuli Wu
Sa Wang
Cheng Liu
Caifang Zhang
Jinjing Guo
Xiaoya Shang
Publication date: 01-06-2019
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 3/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01291-x

At a glance: The STEP trials

Springer Medicine

A new 2H-benzindazole compound from Alternaria alternata Shm-1, an endophytic fungus isolated from the fresh wild fruit of Phellinus igniarius

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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