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European Journal of Nuclear Medicine and Molecular Imaging

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01-07-2021 | Melanoma | Original Article

Assessing immune organs on ¹⁸F-FDG PET/CT imaging for therapy monitoring of immune checkpoint inhibitors: inter-observer variability, prognostic value and evolution during the treatment course of melanoma patients

Authors: Kevin Prigent, Charline Lasnon, Emilien Ezine, Mélanie Janson, Nicolas Coudrais, Elisa Joly, Laure Césaire, Andrea Stefan, Michel Depontville, Nicolas Aide

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 8/2021

Abstract

Background

Immune checkpoint inhibitors (ICIs) have significantly improved survival in advanced melanoma. There is a need for robust biomarkers to identify patients who do not respond. We analysed 14 baseline ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) metrics and their evolution to assess their correlation with patient outcome, compared with 7 established biological markers and 7 clinical variables.

Methods

We conducted a retrospective monocentric observational study of 29 patients with advanced melanoma who underwent baseline ¹⁸F-FDG PET/CT, followed by an early monitoring PET/CT (iPET) scan after 1 month of treatment and follow-up studies at 3rd (M3PET) and 6th month (M6PET). ¹⁸F-FDG uptake in immune organs (spleen, bone marrow, ileocecal valve) and derived spleen-to-liver (SLR) and bone-to-liver (BLR) ratios were reviewed by two PET readers for reproducibility analysis purposes including 14 PET variables. The most reproducible indexes were used for evaluation as predictors of overall survival (OS) in comparison with PET response using imPERCIST5, whole-body metabolic active tumour volume (WB-MATV) and biological parameters (lactate dehydrogenases (LDH), reactive protein c (CRP), white blood count (WBC), absolute lymphocyte count (ALC), neutrophil to lymphocyte ratio (NLR) and derived neutrophils to lymphocyte ratio).

Results

Strong reproducibility’s (intraclass coefficients of correlation (ICC) > 0.90) were observed for spleen anterior SUV_peak, spleen MV, spleen TLG, spleen length and BLR_mean. ICC for SLR_mean and ileocecal SUV_mean were 0.86 and 0.65, respectively. In the 1-year OS 1 group, SLR_mean tended to increase at each time point to reach a significant difference at M6-PET (p = 0.019). The same trends were observed with spleen SUV_peak anterior and spleen length. In the 1-year OS 0 group, a significative increase of spleen length was found at iPET, as compared with baseline PET (p = 0.014) and M3-PET (p = 0.0239). Univariable Kaplan-Meier survival analysis found that i%var spleen length, M3%var SLR_mean, baseline LDH, i%var NLR and response at M6PET were all predictors of 1-year OS.

Conclusions

SLR_mean is recommended as a prognosticator in melanoma patients under immunotherapy: its increase greater than 25% at 3 months, compared with baseline, was associated with poor outcome after ICIs.

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Title: Assessing immune organs on 18F-FDG PET/CT imaging for therapy monitoring of immune checkpoint inhibitors: inter-observer variability, prognostic value and evolution during the treatment course of melanoma patients
Authors: Kevin Prigent
Charline Lasnon
Emilien Ezine
Mélanie Janson
Nicolas Coudrais
Elisa Joly
Laure Césaire
Andrea Stefan
Michel Depontville
Nicolas Aide
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keywords: Melanoma
Melanoma
Checkpoint Inhibitors
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 8/2021
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-020-05103-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Assessing immune organs on ¹⁸F-FDG PET/CT imaging for therapy monitoring of immune checkpoint inhibitors: inter-observer variability, prognostic value and evolution during the treatment course of melanoma patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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