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Published in: European Journal of Nuclear Medicine and Molecular Imaging 1/2019

Open Access 01-01-2019 | Review Article

FDG PET/CT for assessing tumour response to immunotherapy

Report on the EANM symposium on immune modulation and recent review of the literature

Authors: Nicolas Aide, Rodney J. Hicks, Christophe Le Tourneau, Stéphanie Lheureux, Stefano Fanti, Egesta Lopci

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 1/2019

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Abstract

This paper follows the immunotherapy symposium held during the European Association of Nuclear Medicine (EANM) 2017 Annual Congress. The biological basis of the immune checkpoint inhibitors and the drugs most frequently used for the treatment of solid tumours are reviewed. The issues of pseudoprogression (frequency, timeline), hyperprogression and immune-related side effects are discussed, as well as their implications for patient management. A review of the recent literature on the use of FDG PET for assessment of immunotherapy is presented, and recommendations are provided for assessing tumour response and reporting immune-related side effects with FDG PET based on published data and experts’ experience. Representative clinical cases are also discussed.
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Metadata
Title
FDG PET/CT for assessing tumour response to immunotherapy
Report on the EANM symposium on immune modulation and recent review of the literature
Authors
Nicolas Aide
Rodney J. Hicks
Christophe Le Tourneau
Stéphanie Lheureux
Stefano Fanti
Egesta Lopci
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 1/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-018-4171-4

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