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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2013

Open Access 01-12-2013 | Research

Melanoma risk loci as determinants of melanoma recurrence and survival

Authors: Justin Rendleman, Shulian Shang, Christine Dominianni, Jerry F Shields, Patrick Scanlon, Christina Adaniel, Alexis Desrichard, Michelle Ma, Richard Shapiro, Russell Berman, Anna Pavlick, David Polsky, Yongzhao Shao, Iman Osman, Tomas Kirchhoff

Published in: Journal of Translational Medicine | Issue 1/2013

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Abstract

Background

Steadily high melanoma mortality rates urge for the availability of novel biomarkers with a more personalized ability to predict melanoma clinical outcomes. Germline risk variants are promising candidates for this purpose; however, their prognostic potential in melanoma has never been systematically tested.

Methods

We examined the effect of 108 melanoma susceptibility single nucleotide polymorphisms (SNPs), associated in recent GWAS with melanoma and melanoma-related phenotypes, on recurrence-free survival (RFS) and overall survival (OS), in 891 prospectively accrued melanoma patients. Cox proportional hazards models (Cox PH) were used to test the associations between 108 melanoma risk SNPs and RFS and OS adjusted by age at diagnosis, gender, tumor stage, histological subtype and other primary tumor characteristics.

Results

We identified significant associations for rs7538876 (RCC2) with RFS (HR = 1.48, 95% CI = 1.20-1.83, p = 0.0005) and rs9960018 (DLGAP1) with both RFS and OS (HR = 1.43, 95% CI = 1.07-1.91, p = 0.01, HR = 1.52, 95% CI = 1.09-2.12, p = 0.01, respectively) using multivariable Cox PH models. In addition, we developed a logistic regression model that incorporates rs7538876, rs9960018, primary tumor histological type and stage at diagnosis that has an improved discriminatory ability to classify 3-year recurrence (AUC = 82%) compared to histological type and stage alone (AUC = 78%).

Conclusions

We identified associations between melanoma risk variants and melanoma outcomes. The significant associations observed for rs7538876 and rs9960018 suggest a biological implication of these loci in melanoma progression. The observed predictive patterns of associated variants with clinical end-points suggest for the first time the potential for utilization of genetic risk markers in melanoma prognostication.
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Literature
1.
Eheman C, Henley SJ, Ballard-Barbash R, Jacobs EJ, Schymura MJ, Noone AM, Pan L, Anderson RN, Fulton JE, Kohler BA: Annual report to the nation on the status of cancer, 1975–2008, featuring cancers associated with excess weight and lack of sufficient physical activity. Cancer. 2012, 118: 2338-2366. 10.1002/cncr.27514.PubMedCentralCrossRefPubMed
2.
Simard EP, Ward EM, Siegel R, Jemal A: Cancers with increasing incidence trends in the United States: 1999 through 2008. CA Cancer J Clin. 2012, 62: 118-128. 10.3322/caac.20141.CrossRefPubMed
3.
Jemal A, Devesa SS, Hartge P, Tucker MA: Recent trends in cutaneous melanoma incidence among whites in the United States. J Natl Cancer Inst. 2001, 93: 678-683. 10.1093/jnci/93.9.678.CrossRefPubMed
4.
Purdue MP, Freeman LE, Anderson WF, Tucker MA: Recent trends in incidence of cutaneous melanoma among US Caucasian young adults. J Invest Dermatol. 2008, 128: 2905-2908. 10.1038/jid.2008.159.PubMedCentralCrossRefPubMed
5.
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S: Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009, 27: 6199-6206. 10.1200/JCO.2009.23.4799.PubMedCentralCrossRefPubMed
6.
Gershenwald JE, Soong SJ, Balch CM: 2010 TNM staging system for cutaneous melanoma…and beyond. Ann Surg Oncol. 2010, 17: 1475-1477. 10.1245/s10434-010-0986-3.CrossRefPubMed
7.
Schramm SJ, Mann GJ: Melanoma prognosis: a REMARK-based systematic review and bioinformatic analysis of immunohistochemical and gene microarray studies. Mol Cancer Ther. 2011, 10: 1520-1528. 10.1158/1535-7163.MCT-10-0901.CrossRefPubMed
8.
Spatz A, Batist G, Eggermont AM: The biology behind prognostic factors of cutaneous melanoma. Curr Opin Oncol. 2010, 22: 163-168. 10.1097/CCO.0b013e328337fe8f.CrossRefPubMed
9.
Murali R, Goumas C, Kricker A, From L, Busam KJ, Begg CB, Dwyer T, Gruber SB, Kanetsky PA, Orlow I: Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas. Ann Surg Oncol. 2012, 19: 1024-1033. 10.1245/s10434-011-2058-8.PubMedCentralCrossRefPubMed
10.
Murali R, Desilva C, Thompson JF, Scolyer RA: Factors predicting recurrence and survival in sentinel lymph node-positive melanoma patients. Ann Surg. 2011, 253: 1155-1164. 10.1097/SLA.0b013e318214beba.CrossRefPubMed
11.
Liu H, Wei Q, Gershenwald JE, Prieto VG, Lee JE, Duvic M, Grimm EA, Wang LE: Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression. Melanoma Res. 2012, 22: 169-175. 10.1097/CMR.0b013e32834fc46b.PubMedCentralCrossRefPubMed
12.
Davies JR, Randerson-Moor J, Kukalizch K, Harland M, Kumar R, Madhusudan S, Nagore E, Hansson J, Hoiom V, Ghiorzo P: Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study. Pigment Cell Melanoma Res. 2012, 25: 384-394. 10.1111/j.1755-148X.2012.00982.x.PubMedCentralCrossRefPubMed
13.
Frey UH, Fritz A, Rotterdam S, Schmid KW, Potthoff A, Altmeyer P, Siffert W, Brockmeyer NH: GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma. Eur J Med Res. 2010, 15: 422-427. 10.1186/2047-783X-15-10-422.PubMedCentralCrossRefPubMed
14.
Alonso R, Suarez A, Castro P, Lacave AJ, Gutierrez C: Influence of interleukin-10 genetic polymorphism on survival rates in melanoma patients with advanced disease. Melanoma Res. 2005, 15: 53-60. 10.1097/00008390-200502000-00009.CrossRefPubMed
15.
Schrama D, Scherer D, Schneider M, Zapatka M, Brocker EB, Schadendorf D, Ugurel S, Kumar R, Becker JC: ERCC5 p.Asp1104His and ERCC2 p.Lys751Gln polymorphisms are independent prognostic factors for the clinical course of melanoma. J Invest Dermatol. 2011, 131: 1280-1290. 10.1038/jid.2011.35.CrossRefPubMed
16.
James MR, Hayward NK, Dumenil T, Montgomery GW, Martin NG, Duffy DL: Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia. J Invest Dermatol. 2004, 123: 760-762. 10.1111/j.0022-202X.2004.23305.x.CrossRefPubMed
17.
Ibarrola-Villava M, Pena-Chilet M, Fernandez LP, Aviles JA, Mayor M, Martin-Gonzalez M, Gomez-Fernandez C, Casado B, Lazaro P, Lluch A: Genetic polymorphisms in DNA repair and oxidative stress pathways associated with malignant melanoma susceptibility. Eur J Cancer. 2011, 47: 2618-2625. 10.1016/j.ejca.2011.05.011.CrossRefPubMed
18.
Ionita-Laza I, Lee S, Makarov V, Buxbaum JD, Lin X: Sequence kernel association tests for the combined effect of rare and common variants. Am J Hum Genet. 2013, 92: 841-853. 10.1016/j.ajhg.2013.04.015.PubMedCentralCrossRefPubMed
19.
Gallagher DJ, Vijai J, Cronin AM, Bhatia J, Vickers AJ, Gaudet MM, Fine S, Reuter V, Scher HI, Hallden C: Susceptibility loci associated with prostate cancer progression and mortality. Clin Cancer Res. 2010, 16: 2819-2832. 10.1158/1078-0432.CCR-10-0028.PubMedCentralCrossRefPubMed
20.
Fasching PA, Pharoah PD, Cox A, Nevanlinna H, Bojesen SE, Karn T, Broeks A, van Leeuwen FE, Veer LJ v ’t, Udo R: The role of genetic breast cancer susceptibility variants as prognostic factors. Hum Mol Genet. 2012, 21: 3926-3939. 10.1093/hmg/dds159.PubMedCentralCrossRefPubMed
21.
Phipps AI, Newcomb PA, Garcia-Albeniz X, Hutter CM, White E, Fuchs CS, Hazra A, Ogino S, Nan H, Ma J: Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer. Gastroenterology. 2012, 143: 51-54.e4. 10.1053/j.gastro.2012.04.052.PubMedCentralCrossRefPubMed
22.
Wich LG, Hamilton HK, Shapiro RL, Pavlick A, Berman RS, Polsky D, Goldberg JD, Hernando E, Manga P, Krogsgaard M: Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research. Am J Transplant Res. 2009, 1: 35-43.
23.
DeLong ER, DeLong DM, Clarke-Pearson DL: Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988, 44: 837-845. 10.2307/2531595.CrossRefPubMed
24.
Yang TP, Beazley C, Montgomery SB, Dimas AS, Gutierrez-Arcelus M, Stranger BE, Deloukas P, Dermitzakis ET: Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics. 2010, 26: 2474-2476. 10.1093/bioinformatics/btq452.PubMedCentralCrossRefPubMed
25.
Grundberg E, Small KS, Hedman AK, Nica AC, Buil A, Keildson S, Bell JT, Yang TP, Meduri E, Barrett A: Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet. 2012, 44: 1084-1089. 10.1038/ng.2394.PubMedCentralCrossRefPubMed
26.
Wang K, Li M, Hakonarson H: ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 2010, 38: e164-10.1093/nar/gkq603.PubMedCentralCrossRefPubMed
27.
Consortium EP, Birney E, Stamatoyannopoulos JA, Dutta A, Guigo R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007, 447: 799-816. 10.1038/nature05874.CrossRef
28.
Stacey SN, Gudbjartsson DF, Sulem P, Bergthorsson JT, Kumar R, Thorleifsson G, Sigurdsson A, Jakobsdottir M, Sigurgeirsson B, Benediktsdottir KR: Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. Nat Genet. 2008, 40: 1313-1318. 10.1038/ng.234.CrossRefPubMed
29.
Hutchinson PE, Osborne JE, Lear JT, Smith AG, Bowers PW, Morris PN, Jones PW, York C, Strange RC, Fryer AA: Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma. Clin Cancer Res. 2000, 6: 498-504.PubMed
30.
Howell WM, Turner SJ, Bateman AC, Theaker JM: IL-10 promoter polymorphisms influence tumour development in cutaneous malignant melanoma. Genes Immun. 2001, 2: 25-31. 10.1038/sj.gene.6363726.CrossRefPubMed
31.
Hussein MR, Roggero E, Tuthill RJ, Wood GS, Sudilovsky O: Identification of novel deletion Loci at 1p36 and 9p22-21 in melanocytic dysplastic nevi and cutaneous malignant melanomas. Arch Derm. 2003, 139: 816-817. 10.1001/archderm.139.6.816.CrossRefPubMed
32.
Bale SJ, Dracopoli NC, Tucker MA, Clark WH, Fraser MC, Stanger BZ, Green P, Donis-Keller H, Housman DE, Greene MH: Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p. N Engl J Med. 1989, 320: 1367-1372. 10.1056/NEJM198905253202102.CrossRefPubMed
33.
Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL: The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. Dev Cell. 2003, 5: 295-307. 10.1016/S1534-5807(03)00205-3.CrossRefPubMed
34.
Yenjerla M, Panopoulos A, Reynaud C, Fotedar R, Margolis RL: TD-60 is required for interphase cell cycle progression. Cell Cycle. 2013, 12: 837-841. 10.4161/cc.23821.PubMedCentralCrossRefPubMed
35.
Li M, Wang J, Ng SS, Chan CY, He ML, Yu F, Lai L, Shi C, Chen Y, Yew DT: Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation. Cancer. 2009, 115: 4959-4972. 10.1002/cncr.24550.CrossRefPubMed
36.
Hashimoto S, Onodera Y, Hashimoto A, Tanaka M, Hamaguchi M, Yamada A, Sabe H: Requirement for Arf6 in breast cancer invasive activities. Proc Natl Acad Sci U S A. 2004, 101: 6647-6652. 10.1073/pnas.0401753101.PubMedCentralCrossRefPubMed
37.
Xu XZ, Garcia MV, Li TY, Khor LY, Gajapathy RS, Spittle C, Weed S, Lessin SR, Wu H: Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression. Mod Pathol. 2010, 23: 187-196. 10.1038/modpathol.2009.157.PubMedCentralCrossRefPubMed
38.
Emilsson V, Thorleifsson G, Zhang B, Leonardson AS, Zink F, Zhu J, Carlson S, Helgason A, Walters GB, Gunnarsdottir S: Genetics of gene expression and its effect on disease. Nature. 2008, 452: 423-428. 10.1038/nature06758.CrossRefPubMed
39.
Kan R, Yurttas P, Kim B, Jin M, Wo L, Lee B, Gosden R, Coonrod SA: Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices. Dev Biol. 2011, 350: 311-322. 10.1016/j.ydbio.2010.11.033.PubMedCentralCrossRefPubMed
40.
Nan H, Kraft P, Qureshi AA, Guo Q, Chen C, Hankinson SE, Hu FB, Thomas G, Hoover RN, Chanock S: Genome-wide association study of tanning phenotype in a population of European ancestry. J Invest Dermatol. 2009, 129: 2250-2257. 10.1038/jid.2009.62.PubMedCentralCrossRefPubMed
41.
Kuphal S, Bauer R, Bosserhoff AK: Integrin signaling in malignant melanoma. Cancer Metastasis Rev. 2005, 24: 195-222. 10.1007/s10555-005-1572-1.CrossRefPubMed
42.
Greenwald HS, Friedman EB, Osman I: Superficial spreading and nodular melanoma are distinct biological entities: a challenge to the linear progression model. Melanoma Res. 2011, 22: 1-8.CrossRef
43.
Rose AE, Poliseno L, Wang J, Clark M, Pearlman A, Wang G, Vega YSMEC, Medicherla R, Christos PJ, Shapiro R: Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression. Can Res. 2011, 71: 2561-2571. 10.1158/0008-5472.CAN-10-2958.CrossRef
44.
Warycha MA, Christos PJ, Mazumdar M, Darvishian F, Shapiro RL, Berman RS, Pavlick AC, Kopf AW, Polsky D, Osman I: Changes in the presentation of nodular and superficial spreading melanomas over 35 years. Cancer. 2008, 113: 3341-3348. 10.1002/cncr.23955.PubMedCentralCrossRefPubMed
45.
Poliseno L, Haimovic A, Segura MF, Hanniford D, Christos PJ, Darvishian F, Wang J, Shapiro RL, Pavlick AC, Berman RS: Histology-specific MicroRNA alterations in melanoma. J Invest Dermatol. 2012, 132: 1860-1868. 10.1038/jid.2011.451.PubMedCentralCrossRefPubMed
46.
Olsen CM, Zens MS, Stukel TA, Sacerdote C, Chang YM, Armstrong BK, Bataille V, Berwick M, Elwood JM, Holly EA: Nevus density and melanoma risk in women: a pooled analysis to test the divergent pathway hypothesis. Int J Cancer. 2009, 124: 937-944. 10.1002/ijc.24011.PubMedCentralCrossRefPubMed
47.
Whiteman DC, Stickley M, Watt P, Hughes MC, Davis MB, Green AC: Anatomic site, sun exposure, and risk of cutaneous melanoma. J Clin Oncol. 2006, 24: 3172-3177. 10.1200/JCO.2006.06.1325.CrossRefPubMed
48.
Nielsen K, Masback A, Olsson H, Ingvar C: A prospective, population-based study of 40,000 women regarding host factors, UV exposure and sunbed use in relation to risk and anatomic site of cutaneous melanoma. Int J Cancer. 2012, 131: 706-715. 10.1002/ijc.26408.CrossRefPubMed
49.
Zell JA, Cinar P, Mobasher M, Ziogas A, Meyskens FL, Anton-Culver H: Survival for patients with invasive cutaneous melanoma among ethnic groups: the effects of socioeconomic status and treatment. J Clin Oncol. 2008, 26: 66-75. 10.1200/JCO.2007.12.3604.CrossRefPubMed
50.
Cormier JN, Xing Y, Ding M, Lee JE, Mansfield PF, Gershenwald JE, Ross MI, Du XL: Ethnic differences among patients with cutaneous melanoma. Arch Intern Med. 2006, 166: 1907-1914. 10.1001/archinte.166.17.1907.CrossRefPubMed
51.
52.
Han J, Kraft P, Nan H, Guo Q, Chen C, Qureshi A, Hankinson SE, Hu FB, Duffy DL, Zhao ZZ: A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet. 2008, 4: e1000074-10.1371/journal.pgen.1000074.PubMedCentralCrossRefPubMed
53.
Sauerbrei W, Holländer N, Riley RD, Altman D: Evidence-based assessment and application of prognostic markers: the long way from single studies to meta-analysis. Commun Stat. 2006, 35: 1333-1342. 10.1080/03610920600629666.CrossRef
54.
Tudur-Smith C, Williamson PR, Marson AG: Investigating heterogeneity in an individual patient data meta-analysis of time to event outcomes. Stat Med. 2005, 24: 1307-1319. 10.1002/sim.2050.CrossRef
55.
Kyzas PA, Denaxa-Kyza D, Ioannidis JP: Almost all articles on cancer prognostic markers report statistically significant results. Eur J Cancer. 2007, 43: 2559-2579. 10.1016/j.ejca.2007.08.030.CrossRefPubMed
56.
Abo-Zaid G, Sauerbrei W, Riley RD: Individual participant data meta-analysis of prognostic factor studies: state of the art?. BMC Med Res Methodol. 2012, 12: 56-10.1186/1471-2288-12-56.PubMedCentralCrossRefPubMed
57.
Kirkwood JM, Butterfield LH, Tarhini AA, Zarour H, Kalinski P, Ferrone S: Immunotherapy of cancer in 2012. CA Cancer J Clin. 2012, 62: 309-335. 10.3322/caac.20132.PubMedCentralCrossRefPubMed
Metadata
Title
Melanoma risk loci as determinants of melanoma recurrence and survival
Authors
Justin Rendleman
Shulian Shang
Christine Dominianni
Jerry F Shields
Patrick Scanlon
Christina Adaniel
Alexis Desrichard
Michelle Ma
Richard Shapiro
Russell Berman
Anna Pavlick
David Polsky
Yongzhao Shao
Iman Osman
Tomas Kirchhoff
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2013
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-11-279

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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