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01-01-2020 | Medulloblastoma | Clinical Study

Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor

Authors: Andrew M. Heitzer, Alexandra M. Villagran, Kimberly Raghubar, Austin L. Brown, Miranda L. Camet, M. Douglas Ris, Jenny H. Hanning, M. Fatih Okcu, Arnold C. Paulino, Murali Chintagumpala, Lisa S. Kahalley

Published in: Journal of Neuro-Oncology | Issue 1/2020

Abstract

Purpose

Survivors of pediatric embryonal brain tumors (BT) are at high risk for sensorineural hearing loss (SNHL) associated with neurocognitive decline. However, previous studies have not assessed the relationship between SNHL and adaptive functioning. We examined neurocognitive and adaptive functioning in patients with and without SNHL.

Methods

Participants included 36 patients treated for an embryonal BT with craniospinal irradiation (CSI) and cisplatin chemotherapy who were assessed 6.7 years post-treatment on average. The impact of SNHL on neurocognitive performance and parent-rated adaptive functioning was assessed in univariate and multivariate analyses.

Results

There were 17 cases with SNHL (mean age at evaluation = 14.4) and 19 cases with NH (mean age at evaluation = 13.8). After accounting for age at diagnosis and additional covariates in multivariable analyses, SNHL was associated with worse overall intellectual functioning (p = 0.027) and perceptual reasoning (p = 0.016) performance. There was no effect of SNHL on adaptive functioning in multivariable models. Age at diagnosis and sex were associated with performance on neurocognitive measures.

Conclusions

SNHL in pediatric embryonal BT is associated with increased risk for neurocognitive deficits in conjunction with other demographic and treatment-related factors.

The Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) does not generate a PRI score. At our request, NCS Pearson Inc. (publisher of the WISC-V) generated the norms for calculating PRI scores from WISC-V subtests to enable comparison of scores across versions. WISC-V PRI reliabilities ranged from 0.93 to 0.95 across ages 6–16 [50].

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Title: Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor
Authors: Andrew M. Heitzer
Alexandra M. Villagran
Kimberly Raghubar
Austin L. Brown
Miranda L. Camet
M. Douglas Ris
Jenny H. Hanning
M. Fatih Okcu
Arnold C. Paulino
Murali Chintagumpala
Lisa S. Kahalley
Publication date: 01-01-2020
Publisher: Springer US
Keywords: Medulloblastoma
Medulloblastoma
Medulloblastoma
Brain Tumor
Published in: Journal of Neuro-Oncology / Issue 1/2020
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03356-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of sensorineural hearing loss on neurocognitive and adaptive functioning in survivors of pediatric embryonal brain tumor

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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