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Open Access 01-12-2023 | Medulloblastoma | Letter to the Editor

A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma

Authors: Arnault Tauziède-Espariat, Marie Simbozel, Anthony P. Y. Liu, Giles W. Robinson, Julien Masliah-Planchon, Philipp Sievers, Alexandre Vasiljevic, Mathilde Duchesne, Stéphanie Puget, Volodia Dangouloff-Ros, Nathalie Boddaert, Alice Métais, Lauren Hasty, Christelle Dufour, Pascale Varlet

Published in: Acta Neuropathologica Communications | Issue 1/2023

Excerpt

Over the past several years, medulloblastomas have been subdivided into four different subgroups based on genetic and epigenetic data (WNT-activated, SHH-activated, and groups 3 and 4) [7]. It has been evidenced that these subgroups are correlated to their precise anatomic location in the posterior fossa (cerebellar hemispheres vs. dorsal brainstem) and their cell of origin [5]. However, a recent study reported 7 cases of WNT-activated embryonal tumors epicentered in the pineal region that clustered within the DNA-methylation class of medulloblastomas, WNT-activated (MB-WNT) [6]. These results suggest the possibility of a potential novel pineoblastoma subgroup or an ectopic location of medulloblastoma. …

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Algin O, Ozmen E (2015) Ectopic anterior cerebellum (ala lobule centralis). Neuroradiol J 28:278–280. https://doi.org/10.1177/1971400915594512CrossRefPubMedPubMedCentral

Chang AH, Kaufmann WE, Brat DJ (2001) Ectopic cerebellum presenting as a suprasellar mass in infancy: implications for cerebellar development. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc 4:89–93. https://doi.org/10.1007/s100240010128CrossRef

Chung CJ, Castillo M, Fordham L, Mukherji S, Boydston W, Hudgins R (1998) Spinal intradural cerebellar ectopia. AJNR Am J Neuroradiol 19:897–899PubMedPubMedCentral

De Benedictis A, Rossi-Espagnet MC, Diomedi-Camassei F, Rossi S, Fontana E, Randi F, Ponzo V, Nucci C, Esposito G, Paternò G, Brunetti C, Savioli A, Carai A, Marras CE (2020) Intraventricular ectopic cerebellum. World Neurosurg 137:158–163. https://doi.org/10.1016/j.wneu.2020.01.127CrossRefPubMed

Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang Z-J, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ (2010) Subtypes of medulloblastoma have distinct developmental origins. Nature 468:1095–1099. https://doi.org/10.1038/nature09587CrossRefPubMedPubMedCentral

Liu APY, Priesterbach-Ackley LP, Orr BA, Li BK, Gudenas B, Reddingius RE, Suñol M, Lavarino CE, Olaciregui NG, Santa-María López V, Fisher MJ, Hazrati L-N, Bouffet E, Huang A, Robinson GW, Wesseling P, Northcott PA, Gajjar A (2020) WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup? Acta Neuropathol 140:595–597. https://doi.org/10.1007/s00401-020-02208-9CrossRefPubMedPubMedCentral

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro-Oncol 23:1231–1251. https://doi.org/10.1093/neuonc/noab106CrossRefPubMedPubMedCentral

Matyja E, Grajkowska W, Marchel A, Rysz A, Majkowska-Zwolinska B (2007) Ectopic cerebellum in anterior cranial fossa: report of a unique case associated with skull congenital malformations and epilepsy. Am J Surg Pathol 31:322–325. https://doi.org/10.1097/01.pas.0000213404.18311.c9CrossRefPubMed

Title: A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma
Authors: Arnault Tauziède-Espariat
Marie Simbozel
Anthony P. Y. Liu
Giles W. Robinson
Julien Masliah-Planchon
Philipp Sievers
Alexandre Vasiljevic
Mathilde Duchesne
Stéphanie Puget
Volodia Dangouloff-Ros
Nathalie Boddaert
Alice Métais
Lauren Hasty
Christelle Dufour
Pascale Varlet
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Medulloblastoma
Medulloblastoma
Medulloblastoma
Published in: Acta Neuropathologica Communications / Issue 1/2023
Electronic ISSN: 2051-5960
DOI: https://doi.org/10.1186/s40478-023-01556-3

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A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma

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