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Child's Nervous System

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01-02-2021 | Medulloblastoma | Case-Based Review

Benign skull and subdural lesions in patients with prior medulloblastoma therapy

Authors: Kristiyana Kaneva, Nitin Wadhwani, Arthur J. DiPatri Jr, Susan Palasis, Stewart Goldman, Jessie Aw-Zoretic

Published in: Child's Nervous System | Issue 2/2021

Abstract

Purpose

To report on our institutional cohort of patients and review the literature of medulloblastoma patients who developed skull/subdural-based lesions following treatment.

Methods

Following institutional review board (IRB) approval, we retrospectively reviewed the medical records of four children with a history of treated medulloblastoma who developed non-specific skull-based/subdural lesions incidentally found on surveillance imaging.

Results

Biopsies of the lesions proved the pathology to be low grade and included inflammatory myofibroblastic tumor, cortical fibrous defect consistent with fibroma, fibrous tissue, and fibrous dysplasia. The finding of calvarial or subdural fibrous lesions in children following therapy for medulloblastoma was noted in four out of 201 (136 with available follow-up data) medulloblastoma patients seen or discussed in our institution over the past 10 years.

Conclusions

These lesions can grow over time and pose a differential diagnostic challenge with metastatic disease when identified. The skull and subdural space should be scrutinized for secondary lesions on surveillance imaging of patients with medulloblastoma who have received craniospinal irradiation as knowledge of this benign occurrence will assist with management.

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Title: Benign skull and subdural lesions in patients with prior medulloblastoma therapy
Authors: Kristiyana Kaneva
Nitin Wadhwani
Arthur J. DiPatri Jr
Susan Palasis
Stewart Goldman
Jessie Aw-Zoretic
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Medulloblastoma
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Medulloblastoma
Medulloblastoma
Brain Tumor
Published in: Child's Nervous System / Issue 2/2021
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-020-04874-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Benign skull and subdural lesions in patients with prior medulloblastoma therapy

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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