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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 7/2017

01-07-2017 | Review

Medical Management of Pain in Chronic Pancreatitis

Authors: Vikesh K. Singh, Asbjørn M. Drewes

Published in: Digestive Diseases and Sciences | Issue 7/2017

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Abstract

The medical management of pain in chronic pancreatitis continues to pose significant challenges for clinicians caring for these patients. There are increasing data, suggesting that pain in chronic pancreatitis is largely due to peripheral and central sensitization that evolves, over time, as a result of nociceptive afferent associated with chronic inflammation and fibrosis of the pancreas. In many instances, patients rapidly progress to requiring opioid analgesics for the adequate treatment of pain despite the unequivocal risks associated with the long-term use of these drugs. Centrally acting drugs, such as gabapentinoids, appear to be effective means of treating pain due to their inhibition of neurotransmitters involved in central sensitization, but side effects limit their use. The present review explores the evidence for various non-pharmacologic and pharmacologic treatments for pain in chronic pancreatitis.
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Metadata
Title
Medical Management of Pain in Chronic Pancreatitis
Authors
Vikesh K. Singh
Asbjørn M. Drewes
Publication date
01-07-2017
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 7/2017
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4605-z

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