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Open Access 01-12-2013 | Review

Mechanisms of chemoresistance in cancer stem cells

Authors: Lissa Nurrul Abdullah, Edward Kai-Hua Chow

Published in: Clinical and Translational Medicine | Issue 1/2013

Abstract

Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recurrence and ultimately death because of treatment failure. In recent years, cancer stem cells (CSCs) have gained intense interest as key tumor-initiating cells that may also play an integral role in recurrence following chemotherapy. As such, a number of mechanisms of chemoresistance have been identified in CSCs. In this review, we describe a number of these mechanisms of chemoresistance including ABC transporter expression, aldehyde dehydrogenase (ALDH) activity, B-cell lymphoma-2 (BCL2) related chemoresistance, enhanced DNA damage response and activation of key signaling pathways. Furthermore, we evaluate studies that demonstrate potential methods for overcoming chemoresistance and treating chemoresistant cancers that are driven by CSCs. By understanding how tumor-initiating cells such as CSCs escape chemotherapy, more informed approaches to treating cancer will develop and may improve clinical outcomes for cancer patients.

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Title: Mechanisms of chemoresistance in cancer stem cells
Authors: Lissa Nurrul Abdullah
Edward Kai-Hua Chow
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Clinical and Translational Medicine / Issue 1/2013
Electronic ISSN: 2001-1326
DOI: https://doi.org/10.1186/2001-1326-2-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Mechanisms of chemoresistance in cancer stem cells

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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