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Diabetology & Metabolic Syndrome
Published in: Diabetology & Metabolic Syndrome 1/2011

Open Access 01-12-2011 | Review

Mechanism of the mitogenic influence of hyperinsulinemia

Author: Boris Draznin

Published in: Diabetology & Metabolic Syndrome | Issue 1/2011

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Abstract

Either endogenous or exogenous hyperinsulinemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras protein. Increased availability of farnesylated Ras at the plasma membrane enhances mitogenic responsiveness of cells to various growth factors, thus contributing to progression of cancer and atherosclerosis. This effect is specific to insulin, but is not related to the type of insulin used. Stimulatory effect of hyperinsulinemia on farnesyltransferase in the presence of insulin resistance represents one potential mechanism responsible for mitogenicity and atherogenicity of insulin.
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Metadata
Title
Mechanism of the mitogenic influence of hyperinsulinemia
Author
Boris Draznin
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2011
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/1758-5996-3-10

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