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Journal of Bone and Mineral Metabolism
Published in: Journal of Bone and Mineral Metabolism 2/2012

01-03-2012 | Original Article

Measurement of subregional vertebral bone mineral density in vitro using lateral projection dual-energy X-ray absorptiometry: validation with peripheral quantitative computed tomography

Authors: Andrew M. Briggs, Egon Perilli, Ian H. Parkinson, Susan Kantor, Tim V. Wrigley, Nicola L. Fazzalari, John D. Wark

Published in: Journal of Bone and Mineral Metabolism | Issue 2/2012

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Abstract

Although a strong relationship exists between areal bone mineral density (aBMD) derived from dual-energy X-ray absorptiometry (DXA) and bone strength, the predictive validity of aBMD for osteoporotic vertebral fractures remains suboptimal. The diagnostic sensitivity of DXA may be improved by assessing aBMD within vertebral subregions, rather than relying on an estimate derived from the total area of the vertebra. The objective of this study was to validate a method of measuring subregional vertebral aBMD in vitro using lateral-projection DXA against subregional volumetric BMD (vBMD) measured with peripheral quantitative computed tomography (pQCT). A mixed set of 49 lumbar and thoracic vertebrae from 25 donors were scanned using lateral-projection DXA and pQCT. aBMD and apparent vBMD were measured in 7 vertebral regions (1 total area and 6 subregions) from the lateral DXA scan. vBMD was calculated in anatomically equivalent regions from pQCT scan data, using a customised software program designed to increase efficiency of the analysis process. Significant differences in densitometric parameters between subregions were observed by DXA and pQCT (P < 0.01). Subregional vBMD derived from pQCT was explained by a significant proportion of the variance in DXA-derived aBMD (R 2 = 0.51–0.67, P < 0.05) and apparent vBMD (R 2 = 0.64–0.75, P < 0.05). These results confirm the validity of measuring aBMD in vertebral subregions using lateral-projection DXA. The clinical significance should now be explored.
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Metadata
Title
Measurement of subregional vertebral bone mineral density in vitro using lateral projection dual-energy X-ray absorptiometry: validation with peripheral quantitative computed tomography
Authors
Andrew M. Briggs
Egon Perilli
Ian H. Parkinson
Susan Kantor
Tim V. Wrigley
Nicola L. Fazzalari
John D. Wark
Publication date
01-03-2012
Publisher
Springer Japan
Published in
Journal of Bone and Mineral Metabolism / Issue 2/2012
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-011-0307-3

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