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Current Oncology Reports
Published in: Current Oncology Reports 3/2012

01-06-2012 | Gastrointestinal Cancers (L Saltz, Section Editor)

Management of Hepatocellular Carcinoma: Beyond Sorafenib

Authors: Stephen L. Chan, Tony Mok, Brigette B. Y. Ma

Published in: Current Oncology Reports | Issue 3/2012

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Abstract

The positive results of sorafenib have unveiled a new direction of research in the management of hepatocellular carcinoma (HCC). Since then intensive efforts have been focused on development of novel management strategy to further improve the outcome for patients with HCC. Emerging data have suggested that tumor progression of HCC is driven by a number of deregulated signaling pathways and/or epigenetic mechanism. Thus much effort is dedicated to identification of novel agents targeting these dysregulated pathways. Combinations of targeted therapeutics and transarterial chemoembolization (TACE), or different systemic therapeutics also hold the promise to improve treatment outcome beyond sorafenib. This review aims to summarize the current status of clinical development of treatment in HCC. Perspectives on future direction of research will also be discussed.
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Metadata
Title
Management of Hepatocellular Carcinoma: Beyond Sorafenib
Authors
Stephen L. Chan
Tony Mok
Brigette B. Y. Ma
Publication date
01-06-2012
Publisher
Current Science Inc.
Published in
Current Oncology Reports / Issue 3/2012
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-012-0233-0

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