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01-10-2008 | Clinical-Patient Studies

Malignant prolactinoma with craniospinal metastasis in a 12-year-old boy

Authors: Abel Po-Hao Huang, Shih-Hung Yang, Chi-Cheng Yang, Meng-Fai Kuo, Mu Zon Wu, Yong-Kwang Tu

Published in: Journal of Neuro-Oncology | Issue 1/2008

Abstract

The authors report the clinical features of and imaging studies on a rare case of pediatric malignant prolactinoma. A 12-year-old boy presented with ataxia, blurred vision, and consciousness disturbance. He had received transcranial surgery and adjuvant radiotherapy. However, the tumor regrew with craniospinal metastasis 16 months after the operation. The relevant literature was reviewed regarding the clinical presentation, pathogenesis, treatment approaches, and prognosis of malignant prolactinoma.

Kaltsas GA, Nomikos P, Kontogeorgos G et al (2005) Clinical review: diagnosis and management of pituitary carcinomas. J Clin Endocrinol Metab 90:3089–3099CrossRefPubMed

Pernicone PJ, Scheithauer BW, Sebo TJ et al (1997) Pituitary carcinoma: a clinicopathologic study of 15 cases. Cancer 79:804–812CrossRefPubMed

Partington MD, Davis DH, Laws ER Jr et al (1994) Pituitary adenomas in childhood and adolescence. Results of transsphenoidal surgery. J Neurosurg 80:209–216CrossRefPubMed

Kars M, Roelfsema F, Romijn JA et al (2006) Malignant prolactinoma: case report and review of the literature. Eur J Endocrinol 155:523–534CrossRefPubMed

Lamas C, Nunez R, Garcia-Uria J et al (2004) Malignant prolactinoma with multiple bone and pulmonary metastases. J Neurosurg (Pediatrics) 101:116–121CrossRef

Muhr C, Bergstrom M, Lundberg PO et al (1988) Malignant prolactinoma with multiple intracranial metastases studied with positron emission tomography. Neurosurgery 22:374–379CrossRefPubMed

Sironi M, Cenacchi G, Cozzi L et al (2002) Progression on metastatic neuroendocrine carcinoma from a recurrent prolactinoma: a case report. J Clin Pathol 55:148–151PubMed

Roncaroli F, Nose V, Scheithauer BW et al (2003) Gonadotropic pituitary carcinoma: HER-2/neu expression and gene amplification. Report of two cases. J Neurosurg 99:402–408CrossRefPubMed

Thapar K, Kovacs K, Scheithauer BW et al (1996) Proliferative activity and invasiveness among pituitary adenomas and carcinomas: an analysis using the MIB-1 antibody. Neurosurgery 38:99–106CrossRefPubMed

10.

Zafar MS, Mellinger RC, Chason JL (1984) Cushing’s disease due to pituitary carcinoma. Henry Ford Hosp Med J 32:61–66PubMed

11.

Zahedi A, Booth GL, Smyth HS et al (2001) Distinct clonal composition of primary and metastatic adrencorticotrophic hormone-producing pituitary carcinoma. Clin Endocrinol (Oxf) 55:549–556CrossRef

12.

McCutcheon IE, Pieper DR, Fuller GN et al (2000) Pituitary carcinoma containing gonadotropins: treatment by radical excision and cytotoxic chemotherapy: case report. Neurosurgery 46:1233–1239CrossRefPubMed

13.

Mixson AJ, Friedman TC, Katz DA et al (1993) Thyrotropin-secreting pituitary carcinoma. J Clin Endocrinol Metab 76:529–533CrossRefPubMed

14.

Adler JR Jr, Gibbs IC, Puataweepong P et al (2006) Visual field preservation after multisession cyberknife radiosurgery for perioptic lesions. Neurosurgery 59:244–254CrossRefPubMed

15.

Lim S, Shahinian H, Maya MM et al (2006) Temozolomide: a novel treatment for pituitary carcinoma. Lancet Oncol 7:518–520CrossRefPubMed

16.

Fadul CE, Kominsky AL, Meyer LP et al (2006) Long-term response of pituitary carcinoma to temozolomide. Report of two cases. J Neurosurg 105:621–626CrossRefPubMed

17.

Thapar K, Scheithauer BW, Kovacs K et al (1996) p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumor growth fractions. Neurosurgery 38:765–770CrossRefPubMed

18.

Lloyd RV, Kovacs K, Young WF Jr et al (2004) Pituitary tumors. In: DeLellis R, Lloyd RV, Heitz PV (eds) Introduction. WHO classification of tumors of the endocrine organs: pathology and genetics of endocrine organs. IARC Press, Lyon, pp 10–13

19.

Ragel BT, Couldwell WT (2004) Pituitary carcinoma: a review of the literature. Neurosurg Focus 16:E7CrossRefPubMed

20.

Nose-Alberti V, Mesquita MI, Martin LC et al (1998) Adrenocorticotropin-producing pituitary carcinoma with expression of c-erbB-2 and high PCNA index: a comparative study with pituitary adenomas and normal pituitary tissues. Endocr Pathol 9:53–62CrossRefPubMed

21.

Roncaroli F, Scheithauer BW, Young WF et al (2003) Silent corticotroph carcinoma of the adenohypophysis: a report of five cases. Am J Surg Pathol 27:477–486CrossRefPubMed

Title: Malignant prolactinoma with craniospinal metastasis in a 12-year-old boy
Authors: Abel Po-Hao Huang
Shih-Hung Yang
Chi-Cheng Yang
Meng-Fai Kuo
Mu Zon Wu
Yong-Kwang Tu
Publication date: 01-10-2008
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 1/2008
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-008-9626-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Malignant prolactinoma with craniospinal metastasis in a 12-year-old boy

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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