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01-10-2008 | clinical-patient studies

Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients

Authors: Delia Kurzwelly, Claudia A. Müller, Agnieszka Korfel, Eckhard Thiel, Michael Linnebank, Michael Weller, Ulrich Herrlinger

Published in: Journal of Neuro-Oncology | Issue 1/2008

Abstract

Human leukocyte antigens (HLA) are involved in the regulation of immune response to infection and in malignant transformation. Several HLA alleles are associated with immunological or malignant diseases. The aim of the present study was to evaluate a potential association of HLA class I and II alleles with primary central nervous system lymphoma (PCNSL) in immunocompetent patients. We therefore analyzed particular HLA-A, HLA-B and HLA-DRB1 alleles in 82 PCNSL patients and compared the data to those in 327 population controls. No significant difference between these two groups was found using Pearson’s χ² test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL.

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Title: Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients
Authors: Delia Kurzwelly
Claudia A. Müller
Agnieszka Korfel
Eckhard Thiel
Michael Linnebank
Michael Weller
Ulrich Herrlinger
Publication date: 01-10-2008
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 1/2008
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-008-9630-5

At a glance: The STEP trials

Springer Medicine

Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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