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Malaria Journal
Published in: Malaria Journal 1/2002

Open Access 01-12-2002 | Case report

Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

Authors: Quinton L Fivelman, Geoffrey A Butcher, Ipemida S Adagu, David C Warhurst, Geoffrey Pasvol

Published in: Malaria Journal | Issue 1/2002

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Abstract

We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone®. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.
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Metadata
Title
Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
Authors
Quinton L Fivelman
Geoffrey A Butcher
Ipemida S Adagu
David C Warhurst
Geoffrey Pasvol
Publication date
01-12-2002
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2002
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-1-1

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