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Pediatric Radiology
Published in: Pediatric Radiology 2/2017

01-02-2017 | Original Article

Magnetic resonance tissue phase mapping demonstrates altered left ventricular diastolic function in children with chronic kidney disease

Authors: Charlotte Gimpel, Bernd A. Jung, Sabine Jung, Johannes Brado, Daniel Schwendinger, Barbara Burkhardt, Martin Pohl, Katja E. Odening, Julia Geiger, Raoul Arnold

Published in: Pediatric Radiology | Issue 2/2017

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Abstract

Background

Echocardiographic examinations have revealed functional cardiac abnormalities in children with chronic kidney disease.

Objective

To assess the feasibility of MRI tissue phase mapping in children and to assess regional left ventricular wall movements in children with chronic kidney disease.

Materials and methods

Twenty pediatric patients with chronic kidney disease (before or after renal transplantation) and 12 healthy controls underwent tissue phase mapping (TPM) to quantify regional left ventricular function through myocardial long (Vz) and short-axis (Vr) velocities at all 3 levels of the left ventricle.

Results

Patients and controls (age: 8 years—20 years) were matched for age, height, weight, gender and heart rate. Patients had higher systolic blood pressure. No patient had left ventricular hypertrophy on MRI or diastolic dysfunction on echocardiography. Fifteen patients underwent tissue Doppler echocardiography, with normal z-scores for mitral early diastolic (VE), late diastolic (VA) and peak systolic (VS) velocities. Throughout all left ventricular levels, peak diastolic Vz and Vr (cm/s) were reduced in patients: Vzbase -10.6 ± 1.9 vs. -13.4 ± 2.0 (P < 0.0003), Vzmid -7.8 ± 1.6 vs. -11 ± 1.5 (P < 0.0001), Vzapex -3.8 ± 1.6 vs. -5.3 ± 1.6 (P = 0.01), Vrbase -4.2 ± 0.8 vs. -4.9 ± 0.7 (P = 0.01), Vrmid -4.7 ± 0.7 vs. -5.4 ± 0.7 (P = 0.01), Vrapex -4.7 ± 1.4 vs. -5.6 ± 1.1 (P = 0.05).

Conclusion

Tissue phase mapping is feasible in children and adolescents. Children with chronic kidney disease show significantly reduced peak diastolic long- and short-axis left ventricular wall velocities, reflecting impaired early diastolic filling. Thus, tissue phase mapping detects chronic kidney disease-related functional myocardial changes before overt left ventricular hypertrophy or echocardiographic diastolic dysfunction occurs.
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Metadata
Title
Magnetic resonance tissue phase mapping demonstrates altered left ventricular diastolic function in children with chronic kidney disease
Authors
Charlotte Gimpel
Bernd A. Jung
Sabine Jung
Johannes Brado
Daniel Schwendinger
Barbara Burkhardt
Martin Pohl
Katja E. Odening
Julia Geiger
Raoul Arnold
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 2/2017
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-016-3741-5

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