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Child's Nervous System
Published in: Child's Nervous System 8/2020

01-08-2020 | Magnetic Resonance Imaging | Focus Session

Imaging diagnosis of ventriculomegaly: fetal, neonatal, and pediatric

Authors: Usha D. Nagaraj, Beth M. Kline-Fath

Published in: Child's Nervous System | Issue 8/2020

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Abstract

Ventriculomegaly is the term used to describe abnormal enlargement of ventricles in the brain. Neuroimaging, whether it is by ultrasound, computed tomography, or magnetic resonance imaging, is the key to its identification and can help to diagnose its cause and guide management in many cases. The implementation of the imaging modalities and potential differential considerations varies from the fetus, infant, and pediatric patient. Here we discuss how the imaging modalities can be used in these patient populations and review some of the differential considerations.
Literature
1.
Gibbs WN, Tanenbaum LN (2018) Imaging of hydrocephalus. Appl Radiol 47(5):5–13
2.
Goldstein RB, La Pidus AS, Filly RA, Cardoza J (1990) Mild lateral cerebral ventricular dilatation in utero: clinical significance and prognosis. Radiology. 176(1):237–242
3.
Achiron R, Schimmel M, Achiron A, Mashiach S (1993) Fetal mild idiopathic lateral ventriculomegaly: is there a correlation with fetal trisomy? Ultrasound Obstet Gynecol 3(2):89–92
4.
Salomon LJ, Bernard JP, Ville Y (2007) Reference ranges for fetal ventricular width: a non-normal approach. Ultrasound Obstet Gynecol 30(1):61–66
5.
Filly RA, Goldstein RB, Callen PW (1991) Fetal ventricle: importance in routine obstetric sonography. Radiology. 18(1):1–7
6.
Kelly E, Allen V, Seaward G, Windrim R, Ryan G (2001) Mild ventriculomegaly in the fetus, natural history, associated findings and outcome of isolated mild ventriculomegaly: a literature review. Prenat Diagn 21(8):697–700
7.
Chitty LS, Hunt GH, Moore J, Lobb MO (1991) Effectiveness of routine ultrasonography in detecting fetal structural abnormalities in a low risk population. BMJ. 303(6811):1165–1169PubMedPubMedCentral
8.
Cardoza D, Filly A, Goldstein B (1988) Exclusion of fetal ventriculomegaly with a single measurement : the width of the lateral ventricular atrium. Radiology. 169:711–714
9.
Alagappan R, Browning P, Laorr A, McGahan J (1994) Distal lateral ventricular atrium: reevaluation of normal range. Radiology. 193(2):405–408
10.
Griffiths PD, Morris JE, Mason G, Russell SA, Paley MNJ, Whitby EH, Reeves MJ (2011) Fetuses with ventriculomegaly diagnosed in the second trimester of pregnancy by in utero MR imaging: what happens in the third trimester? Am J Neuroradiol 32(3):474–480
11.
Heiserman J, Filly RA, Goldstein RB. Effect of measurement errors on sonographic evaluation of 1991:121–124
12.
Guibaud L (2009) Fetal cerebral ventricular measurement and ventriculomegaly: time for procedure standardization. Ultrasound Obstet Gynecol 34(2):127–130
13.
International Society of Ultrasound in Obstetrics & Gynecology Education Committe. Sonographic examination of the fetal central nervous system : guidelines for performing the ‘ basic examination ’ and the ‘ fetal neurosonogram .’ Ultrasound Obstet Gynecol 2007;29(1):109–116
14.
Morris JE, Rickard S, Paley MNJ, Griffiths PD, Rigby A, Whitby EH (2007) The value of in-utero magnetic resonance imaging in ultrasound diagnosed foetal isolated cerebral ventriculomegaly. Clin Radiol 62:140–144
15.
Li Y, Robertson RL, Robson CD et al (2011) Ultrasound and MRI of fetuses with ventriculomegaly: can cortical development be used to predict postnatal outcome? AJR Am J Roentgenol 196(6):1457–1467PubMedPubMedCentral
16.
Mehta TS, Levine D (2005) Imaging of fetal cerebral ventriculomegaly : a guide to management and outcome. Semin Fetal Neonatal Med 10:421–428
17.
Glenn OA (2010) MR imaging of the fetal brain. Pediatr Radiol 40(1):68–81
18.
Levine D, Trop I, Mehta TS, Barnes PD (2002) MR imaging appearance of fetal cerebral ventricular morphology. Radiology. 223(3):652–660
19.
Garel C, Alberti C (2006) Coronal measurement of the fetal lateral ventricles: comparison between ultrasonography and magnetic resonance imaging. Ultrasound Obstet Gynecol 27(1):23–27
20.
Arduini D, Caforio L, Cavaliere AF, et al. (2013) Manual of diagnostic ultrasound. In: Manual of diagnostic ultrasound. 2nd ed. World Health Organization, 93
21.
Gaglioti P, Oberto M, Todros T (2009) The significance of fetal ventriculomegaly : etiology , short- and long-term outcomes (January):381–388
22.
Falip C, Blanc N, Maes E, Zaccaria I, Oury JF, Sebag G, Garel C (2007) Postnatal clinical and imaging follow-up of infants with prenatal isolated mild ventriculomegaly: a series of 101 cases. Pediatr Radiol 37(10):981–989
23.
Cardoza J, Filly R, Podrasky AE (1988) The dangling choroid plexus : a sonographic observation of value in excluding ventriculomegaly. AJR Am J Roentgenol 151(4):767–770
24.
Nyberg A, Mack A, Hirsch J, Shepard H. Fetal hydrocephalus : detection and clinical of associated significance. :187–191
25.
Weichert J, Hartge D, Krapp M, Germer U, Gembruch U (2010) Prevalence , characteristics and perinatal outcome of fetal ventriculomegaly in 29 , 000 Pregnancies followed at a single institution, (Vm):142–148
26.
Yamasaki M, Nonaka M, Bamba Y, Teramoto C, Ban C, Pooh RK. Seminars in fetal & neonatal medicine diagnosis , treatment , and long-term outcomes of fetal hydrocephalus. Semin Fetal Neonatal Med 2012;17(6):330–335
27.
Garel C, Luton D, Oury JF, Gressens P (2003) Ventricular dilatations. Childs Nerv Syst 19(7–8):517–523
28.
Addario PVD, Pinto V, Pintucci A, Vincenzo P, Pinto V, Pintucci A (2007) Sonographic diagnosis of fetal cerebral ventriculomegaly : an update sonographic diagnosis of fetal cerebral ventriculomegaly : an update. J Matern Neonatal Med 20(1):7–14
29.
Kline-Fath BM, Arroyo MS, Calvo-Garcia MA, Horn PS, Thomas C (2018) Prenatal aqueduct stenosis: association with rhombencephalosynapsis and neonatal outcome. Prenat Diagn 38(13):1028–1034
30.
Heaphy-Henault K, Guimaraes C, Mehollin-Ray A et al (2018) Congenital aqueductal stenosis: findings at fetal MRI that accurately predict a postnatal diagnosis. Am J Neuroradiol 39(5):942–948
31.
Glenn OA, Cuneo AA, Barkovich AJ, Hashemi Z, Bartha AI, Xu D (2012) Malformations of cortical development: diagnostic accuracy of fetal MR imaging. Radiology 263(3):843–855PubMedPubMedCentral
32.
Babcock DS (1995) Sonography of the brain in infants: role in evaluating neurologic abnormalities. AJR Am J Roentgenol 165(2):417–423
33.
Benson JE, Bishop MR, Cohen HL (2002) Intracranial neonatal neurosonography: an update. Ultrasound Q 18(2):89–114
34.
Di Salvo D (2001) A new view of the neonatal brain : clinical utility of supplemental neurologic US imaging windows. Radiographics. 21(4):943–955
35.
Siegel M (2011) Brain. In: Pediatric sonography. Fourth. Philadelphia, PA: Lippencott Williams & Wilkins, 43–48
36.
Mohan S, Rogan EA, Batty R, Raghavan A, Whitby EH, Hart AR, Connolly DJA (2013) CT of the neonatal head. Clin Radiol 68(11):1155–1166
37.
Badve CA, Mallikarjunappa MK, Iyer RS, Ishak GE, Khanna PC (2013) Craniosynostosis: imaging review and primer on computed tomography. Pediatr Radiol 43(6):728–742
38.
Barkovich AJ, Francisco S (1997) The encephalopathic neonate : choosing the proper imaging technique. AJNR Am J Neuroradiol 18:1816–1820
39.
Larovere KL, Brett MS, Tasker RC, Strauss KJ, Burns JP (2012) Head computed tomography scanning during pediatric neurocritical care : diagnostic yield and the utility of portable studies. Neurocrit Care 16:251–257
40.
Merhar SL, Tkach JA, Woods JC, South AP, Wiland EL, Rattan MS, Dumoulin CL, Kline-Fath BM (2017) Neonatal imaging using an on-site small footprint MR scanner. Pediatr Radiol 47:1001–1011
41.
Poland R, Slovis T, Shankaran S (1985) Normal values for ventricular size as determined by real time sonographic techniques. Pediatr Radiol 15:12–14
42.
Perry ANW, Racog DO, Bowman ED, Fracp BS, Murton LJ, De Crespigny LC (1985) Ventricular size in newborn infants. J Ultrasound Med 4(9):475–477
43.
Davies MW, Swaminathan M, Chuang SL, Betheras FR (2000) Reference ranges for the linear dimensions of the intracranial ventricles in preterm neonates. Arch Dis Child Fetal Neonatal Ed 82(3):218–223
44.
Brouwer MJ, de Vries L, Groenendaal F et al (2012) New reference values for the neonatal cerebral ventricles. Radiology. 262(1):224–233
45.
O’Hayon B, Drake J, Ossip M, Tuli S, Clarke M (1998) Frontal and occipital horn ratio : a linear estimate of ventricular size for multiple imaging modalities in pediatric hydrocephalus. Pedatric Neurosurg 29(5):245–249
46.
D’Addario V, Rossi AC (2012) Neuroimaging of ventriculomegaly in the fetal period. Semin Fetal Neonatal Med 17(6):310–318
47.
48.
Marino MA, Morabito R, Vinci S, Germanò A, Briguglio M, Alafaci C, Mormina E, Longo M, Granata F (2014) Benign external hydrocephalus in infants. Neuroradiol J 27(2):245–250
49.
Alvarez LA, Maytal J, Shinnar S (1986) Idiopathic external hydrocephalus: natural history and relationship to benign familial macrocephaly. Pediatrics 77(6):901–907
50.
Zahl SM, Egge A, Helseth E, Wester K (2011) Benign external hydrocephalus: a review, with emphasis on management. Neurosurg Rev 34(4):417–432PubMedPubMedCentral
51.
Tully HM, Dobyns WB (2014) Infantile hydrocephalus: a review of epidemiology, classification and causes. Eur J Med Genet 57(8):359–368PubMedPubMedCentral
52.
Kendall B, Holland I (1981) Benign communicating hydrocephalus in children. Neuroradiology. 21(2):93–96
53.
Hahn FJ, Chu WK, Cheung JY (1984) CT measurements of cranial growth: normal subjects. Am J Roentgenol 142(6):1253–1255
54.
55.
Khan JJ, Donnelly LF, Koch BL et al (2007) A program to decrease the need for pediatric sedation for CT and MRI. Appl Radiol 36(4):30–33
56.
Callahan MJ, MacDougall RD, Bixby SD, Voss SD, Robertson RL, Cravero JP (2018) Ionizing radiation from computed tomography versus anesthesia for magnetic resonance imaging in infants and children: patient safety considerations. Pediatr Radiol 48(1):21–30
57.
Parekh ND, Prabhu SP (2010) Aqueductal web causing obstructive hydrocephalus demonstrated on sagittal FIESTA sequence. Pediatr Radiol 40(SUPPL.1):2010
58.
Fukuhara T, Vorster SJ, Ruggieri P, Luciano MG (1999) Third ventriculostomy patency: comparison of findings at cine phase- contrast MR imaging and at direct exploration. Am J Neuroradiol 20(8):1560–1566
59.
Barton K, Nickerson JP, Higgins T, Williams RK (2018) Pediatric anesthesia and neurotoxicity: what the radiologist needs to know. Pediatr Radiol 48(1):31–36
60.
Patel D, Tubbs R, Pate G, Johnston JJ, Blount J (2014) Fast-sequence MRI studies for surveillance imaging in pediatric hydrocephalus. J Neurosurg Pediatr 13(4):440–447
61.
Boyle TP, Paldino MJ, Kimia AA, Fitz BM, Madsen JR, Monuteaux MC, Nigrovic LE (2014) Comparison of rapid cranial MRI to CT for ventricular shunt malfunction. Pediatrics. 134(1):e47–e54
62.
Ho ML, Rojas R, Eisenberg RL (2012) Cerebral edema. Am J Roentgenol 199(3):258–273
63.
Milohart TH (1992) Classification of the cerebral edemas with reference to hydrocephalus and pseudotumor cerebri. Childs Nerv Syst 8:301–306
64.
Segev Y, Metser U, Beni-Adani L, Elran C, Reider-Groswasser II, Constantini S (2001) Morphometric study of the midsagittal MR imaging plane in cases of hydrocephalus and atrophy and in normal brains. Am J Neuroradiol 22(9):1674–1679
65.
McAllister A, Leach J, West H, Jones B, Zhang B, Serai S (2017) Quantitative synthetic MRI in children: normative intracranial tissue segmentation values during development. Am J Neuroradiol 38(12):2364–2372
66.
Hamza M, Bodensteiner JB, Noorani PA, Barnes PD (1987) Benign extracerebral fluid collections: a cause of macrocrania in infancy. Pediatr Neurol 3(4):218–221
67.
Dyken P, Krawiechi N (1983) Neurodegenerative diseases of infancy and childhoood. Ann Neurol 13(4):351–364
68.
Ibrahim M, Parmar HA, Hoefling N, Srinivasan A (2014) Inborn errors of metabolism: combining clinical and radiologic clues to solve the mystery. Am J Roentgenol 202(3):W315–W327
Metadata
Title
Imaging diagnosis of ventriculomegaly: fetal, neonatal, and pediatric
Authors
Usha D. Nagaraj
Beth M. Kline-Fath
Publication date
01-08-2020
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 8/2020
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-019-04365-z

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