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18-01-2022 | Magnetic Resonance Imaging | Original Article

Volumetric changes within hippocampal subfields in Alzheimer’s disease continuum

Authors: Emre Hari, Elif Kurt, Ali Bayram, Gozde Kizilates-Evin, Burak Acar, Tamer Demiralp, Hakan Gurvit

Published in: Neurological Sciences | Issue 7/2022

Abstract

Neurodegeneration in Alzheimer’s disease continuum (ADC) starts from the transentorhinal cortex and progresses within hippocampal circuitry following the connectivity of its subfields transsynaptically. We aimed to track volumetric changes of the hippocampal subfields by comparing three stages of the ADC. MRI data of 15 patients diagnosed with Alzheimer’s disease dementia (ADD), 15 patients with amnestic mild cognitive impairment (MCI), and 15 individuals with subjective cognitive impairment (SCI) were analyzed. The hippocampal formation was subdivided into CA1, CA3, subiculum (SUB), and dentate gyrus (DG) using FreeSurfer and volumetric values were obtained. The volumetric values were analyzed with ANCOVA and intracranial volume was selected as a covariate. ANCOVA results of the hippocampal subfields displayed statistically significant differences among the three groups in bilateral CA1, SUB, and DG volumes (Right CA1: F = 7.316, p = 0.002; left CA1: F = 6.768, p = 0.003; right SUB: F = 9.390, p < 0.001; left SUB: F = 5.925, p = 0.005; right DG: F = 9.469, p < 0.001; left DG: F = 9.354, p < 0.001), while CA3 volumes were not significantly different among the groups. Post hoc comparisons revealed that volume reductions in bilateral CA1, DG, and SUB were present in ADD compared to both MCI and SCI groups. No significant volumetric changes were found between the SCI and MCI groups. While our results are generally consistent with the literature in terms of the CA1 and SUB findings, they additionally point to the importance of the significant volume loss in DG and the resilience of the CA3 sector.

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Title: Volumetric changes within hippocampal subfields in Alzheimer’s disease continuum
Authors: Emre Hari
Elif Kurt
Ali Bayram
Gozde Kizilates-Evin
Burak Acar
Tamer Demiralp
Hakan Gurvit
Publication date: 18-01-2022
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Alzheimer's Disease
Dementia
Alzheimer's Disease
Dementia
Mild Neurocognitive Disorder
Published in: Neurological Sciences / Issue 7/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-05890-7

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Volumetric changes within hippocampal subfields in Alzheimer’s disease continuum

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