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01-12-2020 | Magnetic Resonance Imaging | Research article

Ultrafast dynamic contrast-enhanced breast MRI may generate prognostic imaging markers of breast cancer

Authors: Natsuko Onishi, Meredith Sadinski, Mary C. Hughes, Eun Sook Ko, Peter Gibbs, Katherine M. Gallagher, Maggie M. Fung, Theodore J. Hunt, Danny F. Martinez, Amita Shukla-Dave, Elizabeth A. Morris, Elizabeth J. Sutton

Published in: Breast Cancer Research | Issue 1/2020

Abstract

Background

Ultrafast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-derived kinetic parameters have demonstrated at least equivalent accuracy to standard DCE-MRI in differentiating malignant from benign breast lesions. However, it is unclear if they have any efficacy as prognostic imaging markers. The aim of this study was to investigate the relationship between ultrafast DCE-MRI-derived kinetic parameters and breast cancer characteristics.

Methods

Consecutive breast MRI examinations between February 2017 and January 2018 were retrospectively reviewed to determine those examinations that meet the following inclusion criteria: (1) BI-RADS 4–6 MRI performed on a 3T scanner with a 16-channel breast coil and (2) a hybrid clinical protocol with 15 phases of ultrafast DCE-MRI (temporal resolution of 2.7–4.6 s) followed by early and delayed phases of standard DCE-MRI. The study included 125 examinations with 142 biopsy-proven breast cancer lesions. Ultrafast DCE-MRI-derived kinetic parameters (maximum slope [MS] and bolus arrival time [BAT]) were calculated for the entire volume of each lesion. Comparisons of these parameters between different cancer characteristics were made using generalized estimating equations, accounting for the presence of multiple lesions per patient. All comparisons were exploratory and adjustment for multiple comparisons was not performed; P values < 0.05 were considered statistically significant.

Results

Significantly larger MS and shorter BAT were observed for invasive carcinoma than ductal carcinoma in situ (DCIS) (P < 0.001 and P = 0.008, respectively). Significantly shorter BAT was observed for invasive carcinomas with more aggressive characteristics than those with less aggressive characteristics: grade 3 vs. grades 1–2 (P = 0.025), invasive ductal carcinoma vs. invasive lobular carcinoma (P = 0.002), and triple negative or HER2 type vs. luminal type (P < 0.001).

Conclusions

Ultrafast DCE-MRI-derived parameters showed a strong relationship with some breast cancer characteristics, especially histopathology and molecular subtype.

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Title: Ultrafast dynamic contrast-enhanced breast MRI may generate prognostic imaging markers of breast cancer
Authors: Natsuko Onishi
Meredith Sadinski
Mary C. Hughes
Eun Sook Ko
Peter Gibbs
Katherine M. Gallagher
Maggie M. Fung
Theodore J. Hunt
Danny F. Martinez
Amita Shukla-Dave
Elizabeth A. Morris
Elizabeth J. Sutton
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Breast Cancer
Breast Cancer
Breast MRI
Published in: Breast Cancer Research / Issue 1/2020
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/s13058-020-01292-9

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