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Acta Neurologica Belgica

Published in:

17-03-2023 | Magnetic Resonance Imaging | Original article

Post-traumatic syringomyelia resolution following surgical treatment: the moniliform syrinx with a better prognosis

Authors: Chunli Lu, Jian Guan, Chenyuan Ding, Xingwen Wang, Zuowei Wang, Zan Chen, Hao Wu, Fengzeng Jian

Published in: Acta Neurologica Belgica | Issue 3/2023

Abstract

Background

Post-traumatic syringomyelia (PTS) presented as a serious delayed complication after spinal cord injury (SCI). In our preliminary pathological investigation of PTS in an animal model, the endogenous repair was activated during the early stage of the central canal expansion. We thought about whether there might be an “early syringomyelia state” with a better outcome.

Objective

This study aimed to further understand the pathophysiological basis of PTS’s occurrence, development, and outcome.

Materials and methods

A cross-sectional observational study from a single-center syringomyelia database prospectively maintained at China International Neuroscience Institute (CHINA-INI). A consecutive series of 28 PTS patients at our institution for surgical treatment met the inclusion criteria of this study. Their clinical and imaging data in a long-term follow-up were reviewed retrospectively. We compared the surgical outcome between moniliform and distended syringomyelia based on high‑resolution MRI and syringomyelia-related symptoms. American Spinal Injury Association (ASIA) impairment scale (AIS) grade to assess their neurological status.

Results

Through a series of phenotypic comparisons, we found that moniliform-like syrinx belongs to a special morphological state with a shorter natural history. The patients in the moniliform group had a better surgical outcome compared with those in the distended group (P = 0.028): more obvious symptom improvement as shown in Kaplan–Meier analysis (P = 0.033, Chi square = 4.523) and a higher syringomyelia resolution rate (P = 0.024).

Conclusion

We consider the delayed post-traumatic syringomyelia with moniliform type with a better surgical outcome and emphasize the importance of timely intervention to restore cerebrospinal fluid circulation.

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Title: Post-traumatic syringomyelia resolution following surgical treatment: the moniliform syrinx with a better prognosis
Authors: Chunli Lu
Jian Guan
Chenyuan Ding
Xingwen Wang
Zuowei Wang
Zan Chen
Hao Wu
Fengzeng Jian
Publication date: 17-03-2023
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Syringomyelia
Published in: Acta Neurologica Belgica / Issue 3/2023
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-023-02233-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Post-traumatic syringomyelia resolution following surgical treatment: the moniliform syrinx with a better prognosis

Abstract

Background

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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