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European Radiology
Published in: European Radiology 8/2019

01-08-2019 | Magnetic Resonance Imaging | Oncology

Pilot study of rapid MR pancreas screening for patients with BRCA mutation

Authors: Giuseppe Corrias, Mitchell C. Raeside, Andrea Agostini, Sandra Huicochea-Castellanos, David Aramburu-Nunez, Ramesh Paudyal, Amita Shukla-Dave, Olga Smelianskaia, Marinela Capanu, Junting Zheng, Maggie Fung, David P. Kelsen, Debra A. Mangino, Mark E. Robson, Deborah J. Goldfrank, Jean Carter, Peter J. Allen, Bettina Conti, Serena Monti, Richard K. G. Do, Lorenzo Mannelli

Published in: European Radiology | Issue 8/2019

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Abstract

Purpose

To develop and optimize a rapid magnetic resonance imaging (MRI) screening protocol for pancreatic cancer to be performed in conjunction with breast MRI screening in breast cancer susceptibility gene (BRCA)–positive individuals.

Methods

An IRB-approved prospective study was conducted. The rapid screening pancreatic MR protocol was designed to be less than 10 min to be performed after a standard breast MRI protocol. Protocol consisted of coronal NT T2 SSFSE, axial NT T2 SSFSE and axial NT rFOV FOCUS DWI, and axial T1. Images were acquired with the patient in the same prone position of breast MRI using the built-in body coil. Image quality was qualitatively assessed by two radiologists with 12 and 13 years of MRI experience, respectively. The imaging protocol was modified until an endpoint of five consecutive patients with high-quality diagnostic images were achieved. Signal-to-noise ratio and contrast-to-noise ratio were assessed.

Results

The rapid pancreas MR protocol was successfully completed in all patients. Diagnostic image quality was achieved for all patients. Excellent image quality was achieved for low b values; however, image quality at higher b values was more variable. In one patient, a pancreatic neuroendocrine tumor was found and the patient was treated surgically. In four patients, small pancreatic cystic lesions were detected. In one subject, a hepatic mass was identified and confirmed as adenoma by liver MRI.

Conclusion

Rapid MR protocol for pancreatic cancer screening is feasible and has the potential to play a role in screening BRCA patients undergoing breast MRI.

Key Point

• Develop and optimize a rapid magnetic resonance imaging (MRI) screening protocol for pancreatic cancer to be performed in conjunction with breast MRI screening in BRCA mutation positive individuals.
Appendix
Available only for authorised users
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Metadata
Title
Pilot study of rapid MR pancreas screening for patients with BRCA mutation
Authors
Giuseppe Corrias
Mitchell C. Raeside
Andrea Agostini
Sandra Huicochea-Castellanos
David Aramburu-Nunez
Ramesh Paudyal
Amita Shukla-Dave
Olga Smelianskaia
Marinela Capanu
Junting Zheng
Maggie Fung
David P. Kelsen
Debra A. Mangino
Mark E. Robson
Deborah J. Goldfrank
Jean Carter
Peter J. Allen
Bettina Conti
Serena Monti
Richard K. G. Do
Lorenzo Mannelli
Publication date
01-08-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 8/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5975-0

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