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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-04-2020 | Magnetic Resonance Imaging | Research Article

Optimization of intravoxel incoherent motion (IVIM): variability of parameters measurements using a reduced distribution of b values for breast tumors analysis

Authors: Natacha Raissa Doudou, Yajie Liu, Sylvanus Kampo, Kai Zhang, Yue Dai, Shaowu Wang

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 2/2020

Abstract

Objectives

This study aimed to examine the variability of intravoxel incoherent motion measurements acquired from reduced distributions of b values for breast tumors analysis.

Materials and methods

The investigations were carried out on twenty-four patients with diagnosed breast tumors. A conventional unenhanced MRI and various IVIM series preset with different distributions of b values (0–1000 s/mm²) were performed. We assessed the variability in D_slow, D_fast, and PF measurements for different distributions of 9 to 4 b values compared with the IVIM metrics for 10 b values using Wilcoxon-Signed rank test. The data was statistically significant at P < 0.05.

Results

The results showed no significant variation in the estimations of IVIM parameters in patients. However, the measurements acquired with the combination of 5 b values Showed some variation in D_fast (P = 0.028) compared with 10 b values. The data showed high wCVs in the measurements acquired using the reduced set of 6 b values for D_slow and PF and with the combination of 7 b values for D_fast. There were inconsistencies noticed in the measurements acquired from malignant tumors using reduced distributions of b values (9 b values–4 b values). However, the set of 4 b values displayed the lowest wCVs for both benign and malignant datasets. We also observed unsystematic correlations among different combinations of b values in the categories of IVIM parameters.

Conclusion

There was no relevant variation in the parameters measurements irrespective of the number of b values used. Reduced distributions of b values may find use in estimations of IVIM parameters for breast lesions analysis.

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Title: Optimization of intravoxel incoherent motion (IVIM): variability of parameters measurements using a reduced distribution of b values for breast tumors analysis
Authors: Natacha Raissa Doudou
Yajie Liu
Sylvanus Kampo
Kai Zhang
Yue Dai
Shaowu Wang
Publication date: 01-04-2020
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 2/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00779-7

At a glance: The STEP trials

Springer Medicine

Optimization of intravoxel incoherent motion (IVIM): variability of parameters measurements using a reduced distribution of b values for breast tumors analysis

Abstract

Objectives

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

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