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Open Access 01-08-2020 | Magnetic Resonance Imaging | Original Communication

Moyamoya angiopathy: radiological follow-up findings in Finnish patients

Authors: Marika Savolainen, Johanna Pekkola, Satu Mustanoja, Tiina Tyni, Juha Hernesniemi, Leena Kivipelto, Turgut Tatlisumak

Published in: Journal of Neurology | Issue 8/2020

Abstract

Background and purpose

Moyamoya angiopathy (MMA) is a chronic progressive disorder, but imaging changes observed over time are not yet characterized in European populations. We analyzed the progression of MMA with magnetic resonance imaging and angiography (MRI and MRA) in our Finnish MMA registry. Stage classification based on MRA findings was used to evaluate the progress of the disease.

Methods

32 patients with MMA were evaluated with MRI and MRA and compared to previous imaging. The follow-up imaging was done 103 (range 6–380) months after the MMA diagnosis, and 64 (range 6–270) months after the previous imaging. We graded the disease stage according to the previously described MRA grading scale.

Results

No acute lesions, including silent ischemic strokes were found in the follow-up image compared to latest available previous image. One patient had an asymptomatic intracerebral hemorrhage since the last imaging. Ivy sign was observed in 22% of the patients in the follow-up image. Six percent (n = 2) had microhemorrhages and 9% (n = 3) white matter lesions in the follow-up imaging. The MRA grade was evaluated from the follow-up images and it was 3 and 2.5 points (right and left, respectively). Fifty-six percent (n = 18) had old ischemic lesions in the follow-up image. Majority (71%) of the old ischemic lesions were large anterior circulation infarcts.

Conclusions

A slow progression of MMA-related changes on MRI/MRA was found, being in line with our previous reports suggesting a rather benign course of the disease in the Finnish population.

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Title: Moyamoya angiopathy: radiological follow-up findings in Finnish patients
Authors: Marika Savolainen
Johanna Pekkola
Satu Mustanoja
Tiina Tyni
Juha Hernesniemi
Leena Kivipelto
Turgut Tatlisumak
Publication date: 01-08-2020
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Journal of Neurology / Issue 8/2020
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-09837-w

2024 ASCO Annual Meeting

Springer Medicine

Moyamoya angiopathy: radiological follow-up findings in Finnish patients

Abstract

Background and purpose

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background and purpose

Methods

Results

Conclusions

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