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European Radiology
Published in: European Radiology 7/2019

01-07-2019 | Magnetic Resonance Imaging | Magnetic Resonance

Modified CAIPIRINHA-VIBE without view-sharing on gadoxetic acid–enhanced multi-arterial phase MR imaging for diagnosing hepatocellular carcinoma: comparison with the CAIPIRINHA-Dixon-TWIST-VIBE

Authors: Seung Baek Hong, Nam Kyung Lee, Suk Kim, Hyeong Il Seo, Hyun Sung Kim, Dong Uk Kim, Tae Un Kim, Hwa Seong Ryu

Published in: European Radiology | Issue 7/2019

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Abstract

Purpose

We evaluated the detection rate and degree of motion artifact of the modified CAIPIRINHA-VIBE (mC-VIBE) without view-sharing and compare them with the CAIPIRINHA-Dixon-TWIST-VIBE (CDT-VIBE) with view-sharing on multi-arterial gadoxetic acid–enhanced liver MRI in the assessment of hepatocellular carcinoma (HCC).

Material and methods

We retrospectively identified 114 pathological-proven hepatic tumors in 114 patients with risk of HCC who underwent multi-arterial gadoxetic acid–enhanced MRI between June 2016 and June 2018. All patients underwent triple arterial phase imaging using the mC-VIBE without view-sharing (54 patients; 49 HCCs and 5 non-HCCs) or the CDT-VIBE with view-sharing (60 patients; 55 HCCs and 5 non-HCCs). We compared the detection rate of two sequences for HCC, with reference to LI-RADS.V.2017. We also compared the mean motion scores and proportions of transient severe motion (TSM) in two sequences.

Result

For the examination using the mC-VIBE, the HCC-detection rate was significantly higher, compared with that using CDT-VIBE (93.9% [46/49] vs 80.0% [44/55], respectively; p = 0.047). For the examination with the mC-VIBE, mean motion scores were significantly lower compared with those of CDT-VIBE for all multi-arterial phases (1.21, 1.19, and 1.15 vs. 1.82, 1.85, and 1.84, respectively; p < 0.001 for all three comparisons). The proportion of TSM in the CDT-VIBE was significantly higher than that in the mC-VIBE (15.0% [9/60] vs 0.0% [0/54], respectively; p = 0.003).

Conclusion

In multi-arterial phase gadoxetic acid–enhanced MRI, the mC-VIBE sequence without view-sharing has slightly higher HCC-detection rate and fewer motion artifacts compared with CDT-VIBE with view-sharing.

Key Points

• Multi-arterial phase using the mC-VIBE without view-sharing can overcome motion artifacts, resulting in providing optimal arterial phase imaging.
• The HCC-detection rate is slightly higher with the mC-VIBE vs. CAIPIRINHA-Dixon-TWIST-VIBE with view-sharing (CDT-VIBE).
• View-sharing of CDT-VIBE in the multi-arterial phase is associated with increased frequency of TSM.
Literature
1.
Mitchell DG, Bruix J, Sherman M, Sirlin CB (2015) LI-RADS (Liver Imaging Reporting and Data System): summary, discussion, and consensus of the LI-RADS Management Working Group and future directions. Hepatology 61:1056–1065CrossRefPubMed
2.
Purysko AS, Remer EM, Coppa CP, Leao Filho HM, Thupili CR, Veniero JC (2012) LI-RADS: a case-based review of the new categorization of liver findings in patients with end-stage liver disease. Radiographics 32:1977–1995CrossRefPubMed
3.
An C, Rakhmonova G, Choi JY, Kim MJ (2016) Liver imaging reporting and data system (LI-RADS) version 2014: understanding and application of the diagnostic algorithm. Clin Mol Hepatol 22:296–307CrossRefPubMedPubMedCentral
4.
Chen N, Motosugi U, Morisaka H et al (2016) Added value of a gadoxetic acid-enhanced hepatocyte-phase image to the LI-RADS system for diagnosing hepatocellular carcinoma. Magn Reson Med Sci 15:49–59CrossRefPubMed
5.
Tirkes T, Mehta P, Aisen AM, Lall C, Akisik F (2015) Comparison of dynamic phase enhancement of hepatocellular carcinoma using gadoxetate disodium vs gadobenate dimeglumine. J Comput Assist Tomogr 39:479–482CrossRefPubMed
6.
Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann HJ (2005) Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 40:715–724CrossRefPubMed
7.
Tamada T, Ito K, Yoshida K et al (2011) Comparison of three different injection methods for arterial phase of Gd-EOB-DTPA enhanced MR imaging of the liver. Eur J Radiol 80:e284–e288CrossRefPubMed
8.
Zech CJ, Vos B, Nordell A et al (2009) Vascular enhancement in early dynamic liver MR imaging in an animal model: comparison of two injection regimen and two different doses Gd-EOB-DTPA (gadoxetic acid) with standard Gd-DTPA. Invest Radiol 44:305–310CrossRefPubMed
9.
Secil M, Obuz F, Altay C et al (2008) The role of dynamic subtraction MRI in detection of hepatocellular carcinoma. Diagn Interv Radiol 14:200–204PubMed
10.
An C, Park MS, Kim D et al (2013) Added value of subtraction imaging in detecting arterial enhancement in small (<3 cm) hepatic nodules on dynamic contrast-enhanced MRI in patients at high risk of hepatocellular carcinoma. Eur Radiol 23:924–930CrossRefPubMed
11.
Fujinaga Y, Ohya A, Tokoro H et al (2014) Radial volumetric imaging breath-hold examination (VIBE) with k-space weighted image contrast (KWIC) for dynamic gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI of the liver: advantages over Cartesian VIBE in the arterial phase. Eur Radiol 24:1290–1299CrossRefPubMed
12.
Pietryga JA, Burke LM, Marin D, Jaffe TA, Bashir MR (2014) Respiratory motion artifact affecting hepatic arterial phase imaging with gadoxetate disodium: examination recovery with a multiple arterial phase acquisition. Radiology 271:426–434CrossRefPubMed
13.
Riffel P, Attenberger UI, Kannengiesser S et al (2013) Highly accelerated T1-weighted abdominal imaging using 2-dimensional controlled aliasing in parallel imaging results in higher acceleration: a comparison with generalized autocalibrating partially parallel acquisitions parallel imaging. Invest Radiol 48:554–561CrossRefPubMed
14.
Yu MH, Lee JM, Yoon JH, Kiefer B, Han JK, Choi BI (2013) Clinical application of controlled aliasing in parallel imaging results in a higher acceleration (CAIPIRINHA)-volumetric interpolated breathhold (VIBE) sequence for gadoxetic acid-enhanced liver MR imaging. J Magn Reson Imaging 38:1020–1026CrossRefPubMed
15.
Breuer FA, Blaimer M, Heidemann RM, Mueller MF, Griswold MA, Jakob PM (2005) Controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) for multi-slice imaging. Magn Reson Med 53:684–691CrossRefPubMed
16.
Wile GE, Leyendecker JR (2010) Magnetic resonance imaging of the liver: sequence optimization and artifacts. Magn Reson Imaging Clin N Am 18(525–547):xi
17.
Vogt FM, Antoch G, Hunold P et al (2005) Parallel acquisition techniques for accelerated volumetric interpolated breath-hold examination magnetic resonance imaging of the upper abdomen: assessment of image quality and lesion conspicuity. J Magn Reson Imaging 21:376–382CrossRefPubMed
18.
Le Y, Kroeker R, Kipfer HD, Lin C (2012) Development and evaluation of TWIST Dixon for dynamic contrast-enhanced (DCE) MRI with improved acquisition efficiency and fat suppression. J Magn Reson Imaging 36:483–491CrossRefPubMed
19.
Michaely HJ, Morelli JN, Budjan J et al (2013) CAIPIRINHA-Dixon-TWIST (CDT)-volume-interpolated breath-hold examination (VIBE): a new technique for fast time-resolved dynamic 3-dimensional imaging of the abdomen with high spatial resolution. Invest Radiol 48:590–597CrossRefPubMed
20.
Kazmierczak PM, Theisen D, Thierfelder KM et al (2015) Improved detection of hypervascular liver lesions with CAIPIRINHA-Dixon-TWIST-volume-interpolated breath-hold examination. Invest Radiol 50:153–160CrossRefPubMed
21.
Ikram NS, Yee J, Weinstein S et al (2017) Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement. Abdom Radiol (NY) 42:870–876CrossRefPubMedCentral
22.
Gruber L, Rainer V, Plaikner M, Kremser C, Jaschke W, Henninger B (2018) CAIPIRINHA-Dixon-TWIST (CDT)-VIBE MR imaging of the liver at 3.0T with gadoxetate disodium: a solution for transient arterial-phase respiratory motion-related artifacts? Eur Radiol 28:2013–2021CrossRefPubMed
23.
24.
Davenport MS, Viglianti BL, Al-Hawary MM et al (2013) Comparison of acute transient dyspnea after intravenous administration of gadoxetate disodium and gadobenate dimeglumine: effect on arterial phase image quality. Radiology 266:452–461CrossRefPubMed
25.
Bruix J, Sherman M, American Association for the Study of Liver Disease (2011) Management of hepatocellular carcinoma: an update. Hepatology 53:1020–1022
26.
Lencioni R, Llovet JM (2010) Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis 30:52–60CrossRefPubMed
27.
Brismar TB, Dahlstrom N, Edsborg N, Persson A, Smedby O, Albiin N (2009) Liver vessel enhancement by Gd-BOPTA and Gd-EOB-DTPA: a comparison in healthy volunteers. Acta Radiol 50:709–715CrossRefPubMed
28.
Tamada T, Ito K, Sone T et al (2009) Dynamic contrast-enhanced magnetic resonance imaging of abdominal solid organ and major vessel: comparison of enhancement effect between Gd-EOB-DTPA and Gd-DTPA. J Magn Reson Imaging 29:636–640CrossRefPubMed
29.
Attenberger UI, Haneder S, Morelli JN, Diehl SJ, Schoenberg SO, Michaely HJ (2010) Peripheral arterial occlusive disease: evaluation of a high spatial and temporal resolution 3-T MR protocol with a low total dose of gadolinium versus conventional angiography. Radiology 257:879–887CrossRefPubMed
30.
Giesel FL, Runge V, Kirchin M et al (2010) Three-dimensional multiphase time-resolved low-dose contrast-enhanced magnetic resonance angiography using TWIST on a 32-channel coil at 3 T: a quantitative and qualitative comparison of a conventional gadolinium chelate with a high-relaxivity agent. J Comput Assist Tomogr 34:678–683CrossRefPubMed
31.
Michaely HJ, Attenberger UI, Dietrich O et al (2008) Feasibility of gadofosveset-enhanced steady-state magnetic resonance angiography of the peripheral vessels at 3 tesla with Dixon fat saturation. Invest Radiol 43:635–641CrossRefPubMed
32.
Davenport MS, Caoili EM, Kaza RK, Hussain HK (2014) Matched within-patient cohort study of transient arterial phase respiratory motion-related artifact in MR imaging of the liver: gadoxetate disodium versus gadobenate dimeglumine. Radiology 272:123–131CrossRefPubMed
33.
Kim SY, Park SH, Wu EH et al (2015) Transient respiratory motion artifact during arterial phase MRI with gadoxetate disodium: risk factor analyses. AJR Am J Roentgenol 204:1220–1227CrossRefPubMed
Metadata
Title
Modified CAIPIRINHA-VIBE without view-sharing on gadoxetic acid–enhanced multi-arterial phase MR imaging for diagnosing hepatocellular carcinoma: comparison with the CAIPIRINHA-Dixon-TWIST-VIBE
Authors
Seung Baek Hong
Nam Kyung Lee
Suk Kim
Hyeong Il Seo
Hyun Sung Kim
Dong Uk Kim
Tae Un Kim
Hwa Seong Ryu
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 7/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06095-x

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