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01-12-2020 | Magnetic Resonance Imaging | Review Article

Hybrid PET/MR imaging in myocardial inflammation post-myocardial infarction

Authors: B. Wilk, BSc, G. Wisenberg, MD, R. Dharmakumar, PhD, J. D. Thiessen, PhD, D. E. Goldhawk, PhD, F. S. Prato, PhD

Published in: Journal of Nuclear Cardiology | Issue 6/2020

Abstract

Hybrid PET/MR imaging is an emerging imaging modality combining positron emission tomography (PET) and magnetic resonance imaging (MRI) in the same system. Since the introduction of clinical PET/MRI in 2011, it has had some impact (e.g., imaging the components of inflammation in myocardial infarction), but its role could be much greater. Many opportunities remain unexplored and will be highlighted in this review. The inflammatory process post-myocardial infarction has many facets at a cellular level which may affect the outcome of the patient, specifically the effects on adverse left ventricular remodeling, and ultimately prognosis. The goal of inflammation imaging is to track the process non-invasively and quantitatively to determine the best therapeutic options for intervention and to monitor those therapies. While PET and MRI, acquired separately, can image aspects of inflammation, hybrid PET/MRI has the potential to advance imaging of myocardial inflammation. This review contains a description of hybrid PET/MRI, its application to inflammation imaging in myocardial infarction and the challenges, constraints, and opportunities in designing data collection protocols. Finally, this review explores opportunities in PET/MRI: improved registration, partial volume correction, machine learning, new approaches in the development of PET and MRI pulse sequences, and the use of novel injection strategies.

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Title: Hybrid PET/MR imaging in myocardial inflammation post-myocardial infarction
Authors: B. Wilk, BSc
G. Wisenberg, MD
R. Dharmakumar, PhD
J. D. Thiessen, PhD
D. E. Goldhawk, PhD
F. S. Prato, PhD
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Myocardial Infarction
Positron Emission Tomography
Published in: Journal of Nuclear Cardiology / Issue 6/2020
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-019-01973-9

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Hybrid PET/MR imaging in myocardial inflammation post-myocardial infarction

Abstract

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Abstract

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