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01-12-2020 | Magnetic Resonance Imaging | Review Article

Hepatic function assessment to predict post-hepatectomy liver failure: what can we trust? A systematic review

Authors: Federico Tomassini, Mariano C. Giglio, Giuseppe De Simone, Roberto Montalti, Roberto I. Troisi

Published in: Updates in Surgery | Issue 4/2020

Abstract

Post hepatectomy liver failure (PHLF) could occur even though an adequate liver volume is preserved. Liver function is not strictly related to the volume and the necessity to pre-operatively predict the future liver remnant (FLR) function is emerging, together with the wide spreading of techniques, aiming to optimize the FLR. The aim of this study was to systematically review all the available tests, to pre-operatively assess the liver function and to estimate the risk of PHLF. A systematic literature research of Medline, Embase, Scopus was performed in accordance to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, to identify all the studies available for pre-operative liver function tests to assess the risk of PHLF and/or complications. From the 1122 references retrieved, 79 were included in the review. Dynamic functional tests, such as indocyanine green test (ICG), could evaluate only global liver function, with no definition of functional capacity of the remnant. Magnetic resonance imaging (MRI) with liver-specific contrast agents enables both liver function and volume evaluation; the absence of ionizing radiation showed a better patient’s compliance. Nuclear imaging studies as hepatobiliary scintigraphy (HBS) present the unique ability to allow a precise evaluation of the segmental liver function of the remnant liver. Liver volume could overestimate liver function. Several liver function tests are available to evaluate the risk of PHLF in the pre-operative setting. However, no single test alone could accurately predict PHLF. Pre-operative combination between a dynamic quantitative test, such as ICG, with MRI or HBS, should enable a more complete functional evaluation. Functional tests to predict PHLF should be chosen according to patient’s characteristics, disease, and center experience.

Bennink RJ, Dinant S, Erdogan D, Heijnen BH, Straatsburg IH, van Vliet AK, van Gulik TM (2004) Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy. J Nucl Med 45(6):965–971PubMed

Tomassini F, D'Asseler Y, Giglio MC, Lecluyse C, Lambert B, Sainz-Barriga M, Van Dorpe J, Hoorens A, Geboes K, Troisi RI (2019) Hemodynamic changes in ALPPS influence liver regeneration and function: results from a prospective study. HPB Off J Int Hepato Pancreato Biliary Assoc 21(5):557–565. https://doi.org/10.1016/j.hpb.2018.09.005CrossRef

Chapelle T, Op de Beeck B, Driessen A, Roeyen G, Bracke B, Hartman V, Huyghe I, Morrison S, Ysebaert D, Francque S (2017) Estimation of the future remnant liver function is a better tool to predict post-hepatectomy liver failure than platelet-based liver scores. Eur J Surg Oncol 43(12):2277–2284. https://doi.org/10.1016/j.ejso.2017.08.009CrossRefPubMed

Olthof PB, Coelen RJS, Bennink RJ, Heger M, Lam MF, Besselink MG, Busch OR, van Lienden KP, van Gulik TM (2017) (99m)Tc-mebrofenin hepatobiliary scintigraphy predicts liver failure following major liver resection for perihilar cholangiocarcinoma. HPB Off J Int Hepato Pancreato Biliary Assoc 19(10):850–858. https://doi.org/10.1016/j.hpb.2017.05.007CrossRef

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8(5):336–341. https://doi.org/10.1016/j.ijsu.2010.02.007CrossRefPubMed

Wagener G (2013) Assessment of hepatic function, operative candidacy, and medical management after liver resection in the patient with underlying liver disease. Semin Liver Dis 33(3):204–212. https://doi.org/10.1055/s-0033-1351777CrossRefPubMed

Mizuguchi T, Kawamoto M, Meguro M, Hui TT, Hirata K (2014) Preoperative liver function assessments to estimate the prognosis and safety of liver resections. Surg Today 44(1):1–10. https://doi.org/10.1007/s00595-013-0534-4CrossRefPubMed

Ge PL, Du SD, Mao YL (2014) Advances in preoperative assessment of liver function. Hepatobiliary Pancreat Dis Int 13(4):361–370. https://doi.org/10.1016/s1499-3872(14)60267-8CrossRefPubMed

de Graaf W, Bennink RJ, Vetelainen R, van Gulik TM (2010) Nuclear imaging techniques for the assessment of hepatic function in liver surgery and transplantation. J Nucl Med 51(5):742–752. https://doi.org/10.2967/jnumed.109.069435CrossRefPubMed

10.

Rassam F, Olthof PB, Bennink RJ, van Gulik TM (2017) Current modalities for the assessment of future remnant liver function. Visc Med 33(6):442–448. https://doi.org/10.1159/000480385CrossRefPubMedPubMedCentral

11.

Ba-Ssalamah A, Bastati N, Wibmer A, Fragner R, Hodge JC, Trauner M, Herold CJ, Bashir MR, Van Beers BE (2017) Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: Where are we? J Magn Reson Imaging 45(3):646–659. https://doi.org/10.1002/jmri.25518CrossRefPubMed

12.

Cieslak KP, Runge JH, Heger M, Stoker J, Bennink RJ, van Gulik TM (2014) New perspectives in the assessment of future remnant liver. Dig Surg 31(4–5):255–268. https://doi.org/10.1159/000364836CrossRefPubMed

13.

Ren Z, Xu Y, Zhu S (2012) Indocyanine green retention test avoiding liver failure after hepatectomy for hepatolithiasis. Hepatogastroenterology 59(115):782–784. https://doi.org/10.5754/hge11453CrossRefPubMed

14.

Uchiyama K, Mori K, Tabuse K, Ueno M, Ozawa S, Nakase T, Kawai M, Tani M, Tanimura H, Yamaue H (2008) Assessment of liver function for successful hepatectomy in patients with hepatocellular carcinoma with impaired hepatic function. J Hepato-Biliary-Pancreat Surg 15(6):596–602. https://doi.org/10.1007/s00534-007-1326-2CrossRef

15.

Sugimoto H, Okochi O, Hirota M, Kanazumi N, Nomoto S, Inoue S, Takeda S, Nakao A (2006) Early detection of liver failure after hepatectomy by indocyanine green elimination rate measured by pulse dye-densitometry. J Hepato-Biliary-Pancreat Surg y 13(6):543–548. https://doi.org/10.1007/s00534-006-1114-4CrossRef

16.

Wakabayashi H, Yachida S, Maeba T, Maeta H (2002) Evaluation of liver function for the application of preoperative portal vein embolization on major hepatic resection. Hepatogastroenterology 49(46):1048–1052PubMed

17.

Fan ST (2002) Methods and related drawbacks in the estimation of surgical risks in cirrhotic patients undergoing hepatectomy. Hepatogastroenterology 49(43):17–20PubMed

18.

Lam CM, Fan ST, Lo CM, Wong J (1999) Major hepatectomy for hepatocellular carcinoma in patients with an unsatisfactory indocyanine green clearance test. Br J Surg 86(8):1012–1017. https://doi.org/10.1046/j.1365-2168.1999.01204.xCrossRefPubMed

19.

Torzilli G, Makuuchi M, Inoue K, Takayama T, Sakamoto Y, Sugawara Y, Kubota K, Zucchi A (1999) No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg 134(9):984–992. https://doi.org/10.1001/archsurg.134.9.984CrossRefPubMed

20.

Lau H, Man K, Fan ST, Yu WC, Lo CM, Wong J (1997) Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy. Br J Surg 84(9):1255–1259PubMed

21.

Okamoto E, Kyo A, Yamanaka N, Tanaka N, Kuwata K (1984) Prediction of the safe limits of hepatectomy by combined volumetric and functional measurements in patients with impaired hepatic function. Surgery 95(5):586–592PubMed

22.

Mizumoto R, Kawarada Y, Noguchi T (1979) Preoperative estimation of operative risk in liver surgery, with special reference to functional reserve of the remnant liver following major hepatic resection. Jpn J Surg 9(4):343–349. https://doi.org/10.1007/bf02468635CrossRefPubMed

23.

Le Roy B, Gregoire E, Cosse C, Serji B, Golse N, Adam R, Cherqui D, Mabrut JY, Le Treut YP, Vibert E (2018) Indocyanine green retention rates at 15 min predicted hepatic decompensation in a western population. World J Surg 42(8):2570–2578. https://doi.org/10.1007/s00268-018-4464-6CrossRefPubMed

24.

Ibis C, Albayrak D, Sahiner T, Soytas Y, Gurtekin B, Sivrikoz N (2017) Value of preoperative indocyanine green clearance test for predicting post-hepatectomy liver failure in noncirrhotic patients. Med Sci Monit 23:4973–4980. https://doi.org/10.12659/msm.907306CrossRefPubMedPubMedCentral

25.

Derpapas MK, Contis J, Fragulidis GP, Lykoudis PM, Polymeneas G, Ntourakis S, Voros D (2013) Correlation of the ICG test with risk factors and postoperative outcomes following hepatic resection. J Balkan Union Oncol 18(3):703–707

26.

Greco E, Nanji S, Bromberg IL, Shah S, Wei AC, Moulton CA, Greig PD, Gallinger S, Cleary SP (2011) Predictors of peri-operative morbidity and liver dysfunction after hepatic resection in patients with chronic liver disease. HPB 13(8):559–565. https://doi.org/10.1111/j.1477-2574.2011.00329.xCrossRefPubMedPubMedCentral

27.

Scheingraber S, Richter S, Igna D, Flesch S, Kopp B, Schilling MK (2008) Indocyanine green disappearance rate is the most useful marker for liver resection. Hepatogastroenterology 55(85):1394–1399PubMed

28.

Zoedler T, Ebener C, Becker H, Roeher HD (1995) Evaluation of liver function tests to predict operative risk in liver surgery. HPB Surg 9(1):13–18. https://doi.org/10.1155/1995/47538CrossRefPubMedPubMedCentral

29.

de Liguori CN, O'Reilly DA, Dajani K, Ghaneh P, Poston GJ, Wu AV (2009) Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure. Eur J Surg Oncol 35(9):957–962. https://doi.org/10.1016/j.ejso.2009.02.003CrossRef

30.

Thomas MN, Weninger E, Angele M, Bosch F, Pratschke S, Andrassy J, Rentsch M, Stangl M, Hartwig W, Werner J, Guba M (2015) Intraoperative simulation of remnant liver function during anatomic liver resection with indocyanine green clearance (LiMON) measurements. HPB 17(6):471–476. https://doi.org/10.1111/hpb.12380CrossRefPubMedPubMedCentral

31.

Weinberg L, Robinson C, Goh SK, Muralidharan V (2018) Use of indocyanine green dye clearance in a patient with liver cirrhosis undergoing hepatectomy: a clinical image. BMJ Case Rep. https://doi.org/10.1136/bcr-2018-225503CrossRefPubMedPubMedCentral

32.

Okochi O, Kaneko T, Sugimoto H, Inoue S, Takeda S, Nakao A (2002) ICG pulse spectrophotometry for perioperative liver function in hepatectomy. J Surg Res 103(1):109–113. https://doi.org/10.1006/jsre.2001.6328CrossRefPubMed

33.

Kambakamba P, Stocker D, Reiner CS, Nguyen-Kim TD, Linecker M, Eshmuminov D, Petrowsky H, Clavien PA, Lesurtel M (2016) Liver kinetic growth rate predicts postoperative liver failure after ALPPS. HPB 18(10):800–805. https://doi.org/10.1016/j.hpb.2016.07.005CrossRefPubMedPubMedCentral

34.

Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M (2016) The predictive value of indocyanine green clearance in future liver remnant for posthepatectomy liver failure following hepatectomy with extrahepatic bile duct resection. World J Surg 40(6):1440–1447. https://doi.org/10.1007/s00268-016-3441-1CrossRefPubMed

35.

Miyagawa S, Makuuchi M, Kawasaki S, Kakazu T (1995) Criteria for safe hepatic resection. Am J Surg 169(6):589–594. https://doi.org/10.1016/s0002-9610(99)80227-xCrossRefPubMed

36.

Wang YY, Zhao XH, Ma L, Ye JZ, Wu FX, Tang J, You XM, Xiang BD, Li LQ (2018) Comparison of the ability of Child–Pugh score, MELD score, and ICG-R15 to assess preoperative hepatic functional reserve in patients with hepatocellular carcinoma. J Surg Oncol 118(3):440–445. https://doi.org/10.1002/jso.25184CrossRefPubMed

37.

Yokoyama Y, Nishio H, Ebata T, Igami T, Sugawara G, Nagino M (2010) Value of indocyanine green clearance of the future liver remnant in predicting outcome after resection for biliary cancer. Br J Surg 97(8):1260–1268. https://doi.org/10.1002/bjs.7084CrossRefPubMed

38.

Kim HJ, Kim CY, Park EK, Hur YH, Koh YS, Kim HJ, Cho CK (2015) Volumetric analysis and indocyanine green retention rate at 15 min as predictors of post-hepatectomy liver failure. HPB 17(2):159–167. https://doi.org/10.1111/hpb.12295CrossRefPubMed

39.

Maruyama M, Yoshizako T, Araki H, Yoshida R, Ando S, Nakamura M, Kitagaki H (2018) Future liver remnant indocyanine green plasma clearance rate as a predictor of post-hepatectomy liver failure after portal vein embolization. Cardiovasc Intervent Radiol 41(12):1877–1884. https://doi.org/10.1007/s00270-018-2065-2CrossRefPubMed

40.

Hwang S, Ha TY, Song GW, Jung DH, Ahn CS, Moon DB, Kim KH, Lee YJ, Lee SG (2015) Quantified risk assessment for major hepatectomy via the indocyanine green clearance rate and liver volumetry combined with standard liver volume. J Gastrointest Surg 19(7):1305–1314. https://doi.org/10.1007/s11605-015-2846-8CrossRefPubMed

41.

Yada K, Morine Y, Ishibashi H, Mori H, Shimada M (2018) Treatment strategy for successful hepatic resection of icteric liver. J Med Investig 65(1.2):37–42. https://doi.org/10.2152/jmi.65.37CrossRef

42.

Vos JJ, Wietasch JK, Absalom AR, Hendriks HG, Scheeren TW (2014) Green light for liver function monitoring using indocyanine green? An overview of current clinical applications. Anaesthesia 69(12):1364–1376. https://doi.org/10.1111/anae.12755CrossRefPubMed

43.

Kokudo T, Hasegawa K, Amikura K, Uldry E, Shirata C, Yamaguchi T, Arita J, Kaneko J, Akamatsu N, Sakamoto Y, Takahashi A, Sakamoto H, Makuuchi M, Matsuyama Y, Demartines N, Malago M, Kokudo N, Halkic N (2016) Assessment of preoperative liver function in patients with hepatocellular carcinoma—the albumin-indocyanine green evaluation (ALICE) grade. PLoS ONE 11(7):e0159530. https://doi.org/10.1371/journal.pone.0159530CrossRefPubMedPubMedCentral

44.

Russolillo N, Forchino F, Conci S, Mele C, Langella S, Ruzzenente A, Scoleri I, Giuliante F, Guglielmi A, Ferrero A (2019) Validation of the albumin-indocyanine green evaluation model in patients with resected hepatocellular carcinoma and comparison with the albumin-bilirubin score. J Hepato-Biliary-Pancreat Sci 26(1):51–57. https://doi.org/10.1002/jhbp.597CrossRef

45.

Miyazaki Y, Kokudo T, Amikura K, Takahashi A, Ohkohchi N, Sakamoto H (2019) Albumin-indocyanine green evaluation grading system predicts post-hepatectomy liver failure for biliary tract cancer. Dig Surg 36(1):13–19. https://doi.org/10.1159/000486142CrossRefPubMed

46.

Stockmann M, Lock JF, Riecke B, Heyne K, Martus P, Fricke M, Lehmann S, Niehues SM, Schwabe M, Lemke AJ, Neuhaus P (2009) Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity. Ann Surg 250(1):119–125. https://doi.org/10.1097/SLA.0b013e3181ad85b5CrossRefPubMed

47.

Stockmann M, Lock JF, Malinowski M, Niehues SM, Seehofer D, Neuhaus P (2010) The LiMAx test: a new liver function test for predicting postoperative outcome in liver surgery. HPB 12(2):139–146. https://doi.org/10.1111/j.1477-2574.2009.00151.xCrossRefPubMedPubMedCentral

48.

Lodewick TM, Alizai PH, van Dam RM, Roeth AAJ, Schmeding M, Heidenhain C, Andert A, Gassler N, Dejong CHC, Neumann UP (2017) Effect of age on liver function in patients undergoing partial hepatectomy. Dig Surg 34(3):233–240. https://doi.org/10.1159/000452494CrossRefPubMedPubMedCentral

49.

Lock JF, Reinhold T, Malinowski M, Pratschke J, Neuhaus P, Stockmann M (2009) The costs of postoperative liver failure and the economic impact of liver function capacity after extended liver resection—a single-center experience. Langenbeck's Arch Surg 394(6):1047–1056. https://doi.org/10.1007/s00423-009-0518-4CrossRef

50.

Malinowski M, Lock JF, Seehofer D, Gebauer B, Schulz A, Demirel L, Bednarsch J, Stary V, Neuhaus P, Stockmann M (2016) Preliminary study on liver function changes after trisectionectomy with versus without prior portal vein embolization. Surg Today 46(9):1053–1061. https://doi.org/10.1007/s00595-015-1293-1CrossRefPubMed

51.

Morris-Stiff G, Gomez D, Prasad R (2009) Quantitative assessment of hepatic function and its relevance to the liver surgeon. J Gastrointest Surg 13(2):374–385. https://doi.org/10.1007/s11605-008-0564-1CrossRefPubMed

52.

Garcea G, Ong SL, Maddern GJ (2009) Predicting liver failure following major hepatectomy. Dig Liver Dis 41(11):798–806. https://doi.org/10.1016/j.dld.2009.01.015CrossRefPubMed

53.

Lorf T, Schnitzbauer AA, Schaefers SK, Scherer MN, Schlitt HJ, Oellerich M, Becker H, Obed A (2008) Prognostic value of the monoethylglycinexylidide (MEGX)-test prior to liver resection. Hepatogastroenterology 55(82–83):539–543PubMed

54.

Wibmer A, Prusa AM, Nolz R, Gruenberger T, Schindl M, Ba-Ssalamah A (2013) Liver failure after major liver resection: risk assessment by using preoperative Gadoxetic acid-enhanced 3-T MR imaging. Radiology 269(3):777–786. https://doi.org/10.1148/radiol.13130210CrossRefPubMed

55.

Sato Y, Matsushima S, Inaba Y, Sano T, Yamaura H, Kato M, Shimizu Y, Senda Y, Ishiguchi T (2015) Preoperative estimation of future remnant liver function following portal vein embolization using relative enhancement on gadoxetic acid disodium-enhanced magnetic resonance imaging. Korean J Radiol 16(3):523–530. https://doi.org/10.3348/kjr.2015.16.3.523CrossRefPubMedPubMedCentral

56.

Barth BK, Fischer MA, Kambakamba P, Lesurtel M, Reiner CS (2016) Liver-fat and liver-function indices derived from Gd-EOB-DTPA-enhanced liver MRI for prediction of future liver remnant growth after portal vein occlusion. Eur J Radiol 85(4):843–849. https://doi.org/10.1016/j.ejrad.2016.02.008CrossRefPubMed

57.

Asenbaum U, Kaczirek K, Ba-Ssalamah A, Ringl H, Schwarz C, Waneck F, Fitschek F, Loewe C, Nolz R (2018) Post-hepatectomy liver failure after major hepatic surgery: not only size matters. Eur Radiol 28(11):4748–4756. https://doi.org/10.1007/s00330-018-5487-yCrossRefPubMedPubMedCentral

58.

Costa AF, Tremblay St-Germain A, Abdolell M, Smoot RL, Cleary S, Jhaveri KS (2017) Can contrast-enhanced MRI with gadoxetic acid predict liver failure and other complications after major hepatic resection? Clin Radiol 72(7):598–605. https://doi.org/10.1016/j.crad.2017.02.004CrossRefPubMed

59.

Cho SH, Kang UR, Kim JD, Han YS, Choi DL (2011) The value of gadoxetate disodium-enhanced MR imaging for predicting posthepatectomy liver failure after major hepatic resection: a preliminary study. Eur J Radiol 80(2):e195–200. https://doi.org/10.1016/j.ejrad.2011.08.008CrossRefPubMed

60.

Kim DK, Choi JI, Choi MH, Park MY, Lee YJ, Rha SE, Jung SE (2018) Prediction of posthepatectomy liver failure: MRI with hepatocyte-specific contrast agent versus indocyanine green clearance test. AJR Am J Roentgenol 211(3):580–587. https://doi.org/10.2214/AJR.17.19206CrossRefPubMed

61.

Yoon JH, Choi JI, Jeong YY, Schenk A, Chen L, Laue H, Kim SY, Lee JM (2016) Pre-treatment estimation of future remnant liver function using gadoxetic acid MRI in patients with HCC. J Hepatol 65(6):1155–1162. https://doi.org/10.1016/j.jhep.2016.07.024CrossRefPubMed

62.

Hwang EH, Taki J, Shuke N, Nakajima K, Kinuya S, Konishi S, Michigishi T, Aburano T, Tonami N (1999) Preoperative assessment of residual hepatic functional reserve using 99mTc-DTPA-galactosyl-human serum albumin dynamic SPECT. J Nucl Med 40(10):1644–1651PubMed

63.

Tanoue Y, Nanashima A, Yano K, Fujii Y, Hiyoshi M, Imamura N, Hamada T, Ikenoue M, Wada T, Mizutani Y, Hirai T (2019) Significance of the preoperative regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the future remnant liver: a sequential study of regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the whole liver. Nucl Med Commun 40(2):145–152. https://doi.org/10.1097/MNM.0000000000000950CrossRefPubMed

64.

Nanashima A, Tobinaga S, Abo T, Nonaka T, Takeshita H, Hidaka S, Sawai T, Nagayasu T (2010) Reducing the incidence of post-hepatectomy hepatic complications by preoperatively applying parameters predictive of liver function. J Hepato-Biliary-Pancreat Sci 17(6):871–878. https://doi.org/10.1007/s00534-010-0281-5CrossRef

65.

Kaibori M, Ha-Kawa SK, Ishizaki M, Matsui K, Saito T, Kwon AH, Kamiyama Y (2008) HA/GSA-Rmax ratio as a predictor of postoperative liver failure. World J Surg 32(11):2410–2418. https://doi.org/10.1007/s00268-008-9725-3CrossRefPubMed

66.

Kokudo N, Vera DR, Tada K, Koizumi M, Seki M, Matsubara T, Ohta H, Yamaguchi T, Takahashi T, Nakajima T, Muto T (2002) Predictors of successful hepatic resection: prognostic usefulness of hepatic asialoglycoprotein receptor analysis. World J Surg 26(11):1342–1347. https://doi.org/10.1007/s00268-002-6262-3CrossRefPubMed

67.

Mizutani Y, Hirai T, Nagamachi S, Nanashima A, Yano K, Kondo K, Hiyoshi M, Imamura N, Terada T (2018) Prediction of posthepatectomy liver failure proposed by the international study group of liver surgery: residual liver function estimation with 99mTc-galactosyl human serum albumin scintigraphy. Clin Nucl Med 43(2):77–81. https://doi.org/10.1097/RLU.0000000000001913CrossRefPubMed

68.

Yoshida M, Shiraishi S, Sakamoto F, Beppu T, Utsunomiya D, Okabe H, Tomiguchi S, Baba H, Yamashita Y (2014) Assessment of hepatic functional regeneration after hepatectomy using (99m)Tc-GSA SPECT/CT fused imaging. Ann Nucl Med 28(8):780–788. https://doi.org/10.1007/s12149-014-0872-3CrossRefPubMed

69.

Mao Y, Du S, Ba J, Li F, Yang H, Lu X, Sang X, Li S, Che L, Tong J, Xu Y, Xu H, Zhao H, Chi T, Liu F, Du Y, Zhang X, Wang X, Dong J, Zhong S, Huang J, Yu Y, Wang J (2015) Using dynamic 99mT c-GSA SPECT/CT fusion images for hepatectomy planning and postoperative liver failure prediction. Ann Surg Oncol 22(4):1301–1307. https://doi.org/10.1245/s10434-014-4117-4CrossRefPubMed

70.

Hayashi H, Beppu T, Okabe H, Kuroki H, Nakagawa S, Imai K, Nitta H, Chikamoto A, Ishiko T, Baba H (2015) Functional assessment versus conventional volumetric assessment in the prediction of operative outcomes after major hepatectomy. Surgery 157(1):20–26. https://doi.org/10.1016/j.surg.2014.06.013CrossRefPubMed

71.

Tatsumi H, Masuda Y, Imaizumi H, Yoshida S, Goto K, Yama N, Mizuguchi T, Hirata K (2013) Asialoglycoprotein receptor scintigraphy with 99mTc-galactosyl human serum albumin (99mTc-GSA) as an early predictor of survival in acute liver failure. Anaesth Intensive Care 41(4):523–528. https://doi.org/10.1177/0310057X1304100414CrossRefPubMed

72.

Nanashima A, Abo T, Arai J, Matsumoto H, Kudo T, Nagayasu T (2013) Functional liver reserve parameters predictive for posthepatectomy complications. J Surg Res 185(1):127–135. https://doi.org/10.1016/j.jss.2013.05.021CrossRefPubMed

73.

Sumiyoshi T, Shima Y, Okabayashi T, Kozuki A, Hata Y, Noda Y, Kouno M, Miyagawa K, Tokorodani R, Saisaka Y, Tokumaru T, Nakamura T, Morita S (2016) Liver function assessment using 99mTc-GSA single-photon emission computed tomography (SPECT)/CT fusion imaging in hilar bile duct cancer: a retrospective study. Surgery 160(1):118–126. https://doi.org/10.1016/j.surg.2016.02.009CrossRefPubMed

74.

Okabayashi T, Shima Y, Morita S, Shimada Y, Sumiyoshi T, Sui K, Iwata J, Iiyama T (2017) Liver function assessment using technetium 99m-galactosyl single-photon emission computed tomography/CT fusion imaging: a prospective trial. J Am Coll Surg 225(6):789–797. https://doi.org/10.1016/j.jamcollsurg.2017.08.021CrossRefPubMed

75.

Sumiyoshi T, Okabayashi T, Negoro Y, Hata Y, Noda Y, Sui K, Iwata J, Matsumoto M (2018) (99m)Tc-GSA SPECT/CT fusion imaging for hepatectomy candidates with extremely deteriorated ICG value. Jpn J Radiol 36(9):537–543. https://doi.org/10.1007/s11604-018-0753-0CrossRefPubMed

76.

Yoshida M, Beppu T, Shiraishi S, Tsuda N, Sakamoto F, Kuramoto K, Okabe H, Nitta H, Imai K, Tomiguchi S, Baba H, Yamashita Y (2018) Liver function in areas of hepatic venous congestion after hepatectomy for liver cancer: (99m)Tc-GSA SPECT/CT fused imaging study. Anticancer Res 38(5):3089–3095. https://doi.org/10.21873/anticanres.12567CrossRefPubMed

77.

Nakamura I, Iimuro Y, Hai S, Kondo Y, Hatano E, Fujimoto J (2018) Impaired value of 99m Tc-GSA scintigraphy as an independent risk factor for posthepatectomy liver failure in patients with hepatocellular carcinoma. Eur Surg Res 59(1–2):12–22. https://doi.org/10.1159/000484044CrossRefPubMed

78.

Yumoto Y, Yagi T, Sato S, Nouso K, Kobayashi Y, Ohmoto M, Yumoto E, Nagaya I, Nakatsukasa H (2010) Preoperative estimation of remnant hepatic function using fusion images obtained by (99m)Tc-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography. Br J Surg 97(6):934–944. https://doi.org/10.1002/bjs.7025CrossRefPubMed

79.

Chiba N, Yokozuka K, Ochiai S, Gunji T, Okihara M, Sano T, Tomita K, Tsutsui R, Kawachi S (2018) The diagnostic value of 99m-Tc GSA scintigraphy for liver function and remnant liver volume in hepatic surgery: a retrospective observational cohort study in 27 patients. Patient Saf Surg 12:15. https://doi.org/10.1186/s13037-018-0161-5CrossRefPubMedPubMedCentral

80.

Nishiyama Y, Yamamoto Y, Hino I, Satoh K, Wakabayashi H, Ohkawa M (2003) 99mTc galactosyl human serum albumin liver dynamic SPET for pre-operative assessment of hepatectomy in relation to percutaneous transhepatic portal embolization. Nucl Med Commun 24(7):809–817. https://doi.org/10.1097/00006231-200307000-00011CrossRefPubMed

81.

Yano K, Nanashima A, Fujii Y, Hiyoshi M, Imamura N, Hamada T, Tsuchimochi Y, Wada T, Mizutani Y, Hirai T (2017) Preoperative regional maximal removal rate of technetium-99m-galactosyl human serum albumin is correlated with liver functional parameters, but did not predict postoperative morbidity. Nucl Med Commun 38(8):701–707. https://doi.org/10.1097/MNM.0000000000000702CrossRefPubMed

82.

Kwon AH, Ha-Kawa SK, Uetsuji S, Inoue T, Matsui Y, Kamiyama Y (1997) Preoperative determination of the surgical procedure for hepatectomy using technetium-99m-galactosyl human serum albumin (99mTc-GSA) liver scintigraphy. Hepatology 25(2):426–429. https://doi.org/10.1002/hep.510250228CrossRefPubMed

83.

Kwon AH, Matsui Y, Kaibori M, Ha-Kawa SK (2006) Preoperative regional maximal removal rate of technetium-99m-galactosyl human serum albumin (GSA-Rmax) is useful for judging the safety of hepatic resection. Surgery 140(3):379–386. https://doi.org/10.1016/j.surg.2006.02.011CrossRefPubMed

84.

Kobayashi K, Hattori N, Manabe O, Hirata K, Magota K, Shimamura T, Tamaki N (2015) Postoperative assessment of hepatic asialoglycoprotein receptor function with Tc-99m GSA: the safety margin of resection size in living donor liver transplantation. Ann Transplant 20:51–58. https://doi.org/10.12659/AOT.892490CrossRefPubMed

85.

Geisel D, Ludemann L, Froling V, Malinowski M, Stockmann M, Baron A, Gebauer B, Seehofer D, Prasad V, Denecke T (2015) Imaging-based evaluation of liver function: comparison of (9)(9)mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI. Eur Radiol 25(5):1384–1391. https://doi.org/10.1007/s00330-014-3536-8CrossRefPubMed

86.

de Graaf W, van Lienden KP, Dinant S, Roelofs JJ, Busch OR, Gouma DJ, Bennink RJ, van Gulik TM (2010) Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection. J Gastrointest Surg 14(2):369–378. https://doi.org/10.1007/s11605-009-1085-2CrossRefPubMed

87.

Rassam F, Olthof PB, Richardson H, van Gulik TM, Bennink RJ (2019) Practical guidelines for the use of technetium-99m mebrofenin hepatobiliary scintigraphy in the quantitative assessment of liver function. Nucl Med Commun 40(4):297–307. https://doi.org/10.1097/MNM.0000000000000973CrossRefPubMed

88.

Hoekstra LT, de Graaf W, Nibourg GA, Heger M, Bennink RJ, Stieger B, van Gulik TM (2013) Physiological and biochemical basis of clinical liver function tests: a review. Ann Surg 257(1):27–36. https://doi.org/10.1097/SLA.0b013e31825d5d47CrossRefPubMed

89.

Tomassini F, D'Asseler Y, Linecker M, Giglio MC, Castro-Benitez C, Truant S, Axelsson R, Olthof PB, Montalti R, Serenari M, Chapelle T, Lucidi V, Sparrelid E, Adam R, Van Gulik T, Pruvot FR, Clavien PA, Bruzzese D, Geboes K, Troisi RI (2020) Hepatobiliary scintigraphy and kinetic growth rate predict liver failure after ALPPS: a multi-institutional study. HPB. https://doi.org/10.1016/j.hpb.2020.01.010CrossRefPubMed

90.

Cieslak KP, Bennink RJ, de Graaf W, van Lienden KP, Besselink MG, Busch OR, Gouma DJ, van Gulik TM (2016) Measurement of liver function using hepatobiliary scintigraphy improves risk assessment in patients undergoing major liver resection. HPB 18(9):773–780. https://doi.org/10.1016/j.hpb.2016.06.006CrossRefPubMedPubMedCentral

91.

Chapelle T, Op De Beeck B, Huyghe I, Francque S, Driessen A, Roeyen G, Ysebaert D, De Greef K (2016) Future remnant liver function estimated by combining liver volumetry on magnetic resonance imaging with total liver function on (99m)Tc-mebrofenin hepatobiliary scintigraphy: can this tool predict post-hepatectomy liver failure? HPB 18(6):494–503. https://doi.org/10.1016/j.hpb.2015.08.002CrossRefPubMedPubMedCentral

92.

Chapelle T, Op de Beeck B, Roeyen G, Bracke B, Hartman V, De Greef K, Huyghe I, Van der Zijden T, Morrison S, Francque S, Ysebaert D (2017) Measuring future liver remnant function prior to hepatectomy may guide the indication for portal vein occlusion and avoid posthepatectomy liver failure: a prospective interventional study. HPB 19(2):108–117. https://doi.org/10.1016/j.hpb.2016.11.005CrossRefPubMed

93.

Olthof PB, Tomassini F, Huespe PE, Truant S, Pruvot FR, Troisi RI, Castro C, Schadde E, Axelsson R, Sparrelid E, Bennink RJ, Adam R, van Gulik TM, de Santibanes E (2017) Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy: Liver volume overestimates liver function. Surgery 162(4):775–783. https://doi.org/10.1016/j.surg.2017.05.022CrossRefPubMed

94.

Sparrelid E, Jonas E, Tzortzakakis A, Dahlen U, Murquist G, Brismar T, Axelsson R, Isaksson B (2017) Dynamic evaluation of liver volume and function in associating liver partition and portal vein ligation for staged hepatectomy. J Gastrointest Surg 21(6):967–974. https://doi.org/10.1007/s11605-017-3389-yCrossRefPubMedPubMedCentral

95.

Truant S, Baillet C, Deshorgue AC, El Amrani M, Huglo D, Pruvot FR (2017) Contribution of hepatobiliary scintigraphy in assessing ALPPS most suited timing. Updates Surg 69(3):411–419. https://doi.org/10.1007/s13304-017-0481-5CrossRefPubMed

96.

de Graaf W, van Lienden KP, van den Esschert JW, Bennink RJ, van Gulik TM (2011) Increase in future remnant liver function after preoperative portal vein embolization. Br J Surg 98(6):825–834. https://doi.org/10.1002/bjs.7456CrossRefPubMed

97.

Truant S, Baillet C, Fulbert M, Olivier A, Sergent G, Turpin A, Boleslawski E, El Amrani M, Huglo D, Pruvot FR (2019) Asymmetric kinetics of volume and function of the remnant liver after major hepatectomy as a key for postoperative outcome—a case-matched study. HPB. https://doi.org/10.1016/j.hpb.2019.10.008CrossRefPubMed

98.

Cieslak KP, Huisman F, Bais T, Bennink RJ, van Lienden KP, Verheij J, Besselink MG, Busch ORC, van Gulik TM (2017) Future remnant liver function as predictive factor for the hypertrophy response after portal vein embolization. Surgery 162(1):37–47. https://doi.org/10.1016/j.surg.2016.12.031CrossRefPubMed

99.

Serenari M, Pettinato C, Bonatti C, Zanoni L, Odaldi F, Cucchetti A, Ravaioli M, Fanti S, Pinna AD, Cescon M (2019) Hepatobiliary scintigraphy in the preoperative evaluation of potential living liver donors. Transpl Proc 51(1):167–170. https://doi.org/10.1016/j.transproceed.2018.04.087CrossRef

100.

Makuuchi M, Hasegawa H, Yamazaki S (1986) Indication for hepatectomy in patients with hepatocellular carcinoma and cirrhosis. Shindan Chiryo 74:1225–1230

101.

Takasaki K (1986) Selection of operative procedure for primary hepatocellular carcinoma, complicated with live cirrhosis—criteria on control of volume in hepatic resection in consideration of security radicality and new deloped anatomically systemized hepatic resection. Jpn J Gastroenterol Surg 19:1881–1889CrossRef

102.

Narasaki H, Noji T, Wada H, Ebihara Y, Tsuchikawa T, Okamura K, Tanaka E, Shichinohe T, Hirano S (2017) Intraoperative real-time assessment of liver function with near-infrared fluorescence imaging. Eur Surg Res 58(5–6):235–245. https://doi.org/10.1159/000477347CrossRefPubMed

Title: Hepatic function assessment to predict post-hepatectomy liver failure: what can we trust? A systematic review
Authors: Federico Tomassini
Mariano C. Giglio
Giuseppe De Simone
Roberto Montalti
Roberto I. Troisi
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Liver Function Test
Liver Surgery
Liver Resection
Liver Surgery
Liver Resection
Published in: Updates in Surgery / Issue 4/2020
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI: https://doi.org/10.1007/s13304-020-00859-7

At a glance: The STEP trials

Springer Medicine

Hepatic function assessment to predict post-hepatectomy liver failure: what can we trust? A systematic review

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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