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Open Access 01-12-2020 | Magnetic Resonance Imaging | Research article

Haemodynamic activity characterization of resting state networks by fractal analysis and thalamocortical morphofunctional integrity in chronic migraine

Authors: Camillo Porcaro, Antonio Di Renzo, Emanuele Tinelli, Giorgio Di Lorenzo, Vincenzo Parisi, Francesca Caramia, Marco Fiorelli, Vittorio Di Piero, Francesco Pierelli, Gianluca Coppola

Published in: The Journal of Headache and Pain | Issue 1/2020

Abstract

Background

Chronic migraine (CM) can be associated with aberrant long-range connectivity of MRI-derived resting-state networks (RSNs). Here, we investigated how the fractal dimension (FD) of blood oxygenation level dependent (BOLD) activity may be used to estimate the complexity of RSNs, reflecting flexibility and/or efficiency in information processing in CM patients respect to healthy controls (HC).

Methods

Resting-state MRI data were collected from 20 untreated CM without history of medication overuse and 20 HC. On both groups, we estimated the Higuchi’s FD. On the same subjects, fractional anisotropy (FA) and mean diffusivity (MD) values of bilateral thalami were retrieved from diffusion tensor imaging and correlated with the FD values.

Results

CM showed higher FD values within dorsal attention system (DAS) and the anterior part of default-mode network (DMN), and lower FD values within the posterior DMN compared to HC. Although FA and MD were within the range of normality, both correlated with the FD values of DAS.

Conclusions

FD of DAS and DMN may reflect disruption of cognitive control of pain in CM. Since the normal microstructure of the thalamus and its positive connectivity with the cortical networking found in our CM patients reminds similar results obtained assessing the same structures but with the methods of neurophysiology, in episodic migraine during an attack, this may be yet another evidence in supporting CM as a never-ending migraine attack.

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Title: Haemodynamic activity characterization of resting state networks by fractal analysis and thalamocortical morphofunctional integrity in chronic migraine
Authors: Camillo Porcaro
Antonio Di Renzo
Emanuele Tinelli
Giorgio Di Lorenzo
Vincenzo Parisi
Francesca Caramia
Marco Fiorelli
Vittorio Di Piero
Francesco Pierelli
Gianluca Coppola
Publication date: 01-12-2020
Publisher: Springer Milan
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Migraine
Published in: The Journal of Headache and Pain / Issue 1/2020
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-020-01181-8

2024 ASCO Annual Meeting

Springer Medicine

Haemodynamic activity characterization of resting state networks by fractal analysis and thalamocortical morphofunctional integrity in chronic migraine

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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