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Published in: Journal of Medical Case Reports 1/2021

Open Access 01-12-2021 | Magnetic Resonance Imaging | Case report

Gummatous neurosyphilis in an elderly patient in the Australian outback: a case report

Authors: Nilesh Anand Devanand, Krishnaswamy Sundararajan

Published in: Journal of Medical Case Reports | Issue 1/2021

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Abstract

Introduction

Neurosyphilis is an infection caused by the spirochete Treponema pallidum, which causes infiltration and thickening of brain meninges. Despite being an Old World disease, the rates of infection continue to rise. This clinical challenge involves early and accurate diagnosis, as neurosyphilis masquerades with various clinical symptoms and is often missed during initial presentation to the hospital. A comprehensive history and clinical examination are essential to detect suspicious cases early for further cerebrospinal fluid examination and neuroimaging. Patients treated with benzylpenicillin for a specific duration often show promising clinical and cognitive improvement, thus emphasizing the need for constant vigilance in our day-to-day practice.

Case presentation

A 77-year-old Caucasian gentleman presented to our hospital repeatedly with multiple episodes of presyncope and cognitive impairment. He also demonstrated bilateral deafness, tabes dorsalis, and left sixth cranial nerve palsy. His cerebrospinal fluid examination showed a nonreactive venereal disease research laboratory test, and magnetic resonance imaging of the brain revealed a gumma.

Conclusion

The diagnosis of neurosyphilis in the elderly requires a combination of clinical vigilance and a high index of suspicion, along with multimodal investigations, including cerebrospinal fluid examination and brain imaging.
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Metadata
Title
Gummatous neurosyphilis in an elderly patient in the Australian outback: a case report
Authors
Nilesh Anand Devanand
Krishnaswamy Sundararajan
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2021
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-021-03153-1

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