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Open Access 03-08-2023 | Magnetic Resonance Imaging | Neurology and Preclinical Neurological Studies - Original Article

Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy

Authors: Sofia Cuoco, Sara Ponticorvo, Filomena Abate, Maria Francesca Tepedino, Roberto Erro, Renzo Manara, Gianfranco Di Salle, Francesco Di Salle, Maria Teresa Pellecchia, Fabrizio Esposito, Paolo Barone, Marina Picillo

Published in: Journal of Neural Transmission | Issue 10/2023

Abstract

Neuropsychiatric symptoms are intrinsic to Progressive Supranuclear Palsy (PSP) and a spoonful of studies investigated their imaging correlates. Describe (I) the frequency and severity of neuropsychiatric symptoms in PSP and (II) their structural imaging correlates. Twenty-six PSP patients underwent Neuropsychiatric Inventory (NPI) and brain 3D T1-weighted MRI. Spearman’s rho with Bonferroni correction was used to investigate correlations between NPI scores and volumes of gray matter regions. More than 80% of patients presented at least one behavioral symptom of any severity. The most frequent and severe were depression/dysphoria, apathy, and irritability/lability. Significant relationships were found between the severity of irritability and right pars opercularis volume (p < 0.001) as well as between the frequency of agitation/aggression and left lateral occipital volume (p < 0.001). Depression, apathy, and irritability are the most common neuropsychiatric symptoms in PSP. Moreover, we found a relationship between specific positive symptoms as irritability and agitation/aggression and greater volume of the right pars opercularis cortex and lower volume of the left occipital cortex, respectively, which deserve further investigations.

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Title: Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy
Authors: Sofia Cuoco
Sara Ponticorvo
Filomena Abate
Maria Francesca Tepedino
Roberto Erro
Renzo Manara
Gianfranco Di Salle
Francesco Di Salle
Maria Teresa Pellecchia
Fabrizio Esposito
Paolo Barone
Marina Picillo
Publication date: 03-08-2023
Publisher: Springer Vienna
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Agitation
Dysthymic Disorder
Mood Disorders
Affective Disorder
Progressive Supranuclear Palsy
Published in: Journal of Neural Transmission / Issue 10/2023
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-023-02676-9

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Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy

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