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Insights into Imaging

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Open Access 01-12-2023 | Magnetic Resonance Imaging | Original Article

Focal breast edema and breast edema score on T2-weighted images provides valuable biological information for invasive breast cancer

Authors: Yanhong Chen, Lijun Wang, Ran Luo, Huanhuan Liu, Yuzhen Zhang, Dengbin Wang

Published in: Insights into Imaging | Issue 1/2023

Abstract

Background

Various features extracted from breast MRI have the potential to serve as noninvasive biomarkers for the prediction of the biologic behavior of breast cancer. The purpose of this study was to investigate the value of focal breast edema and breast edema score (BES) on T2-weighted images in providing valuable biological information for breast cancer patients’ personalized treatment.

Method

Two hundred and five lesions in 201 patients with invasive breast cancer confirmed by surgery or biopsy in Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from November 2018 to October 2019 were retrospectively recruited and analyzed in this study. Focal edema and BES were evaluated at fat-suppressed T2 weighted imaging. All the lesions were divided into two groups according to the presence of focal edema. The differences in clinicopathological characteristics between the two groups and between different BES were compared.

Results

Two hundred and five lesions in 201 patients with invasive breast cancer were retrospectively recruited and analyzed in this study. On the fat-suppressed T2WI, focal edema was detected in 102 of 205 lesions (49.8%). BES was positively correlated with tumor size (p < 0.001), histologic grade (p = 0.006), Ki-67 index (p < 0.001), and N stage (p = 0.007), and was negatively correlated with expression of ER and PR (p < 0.001). Higher BES was more likely to present in patients with non-luminal breast cancer (p < 0.001) and suggested the possibility of a higher N stage.

Conclusions

Focal edema on T2WI of breast MRI indicates stronger tumor invasiveness, in which non-luminal breast cancer is more inclined to present focal edema. Breast edema score, a novel and practical tool, helps guide the individualized treatment of patients with invasive breast cancer.

Graphical Abstract

Critical relevance statement

Focal edema on T2WI of breast MRI indicates stronger tumor invasiveness. Breast edema score helps guide the individualized treatment of patients with invasive breast cancer.

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Title: Focal breast edema and breast edema score on T2-weighted images provides valuable biological information for invasive breast cancer
Authors: Yanhong Chen
Lijun Wang
Ran Luo
Huanhuan Liu
Yuzhen Zhang
Dengbin Wang
Publication date: 01-12-2023
Publisher: Springer Vienna
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Metastasis
Breast Cancer
Edema
Breast Cancer
Breast MRI
Published in: Insights into Imaging / Issue 1/2023
Electronic ISSN: 1869-4101
DOI: https://doi.org/10.1186/s13244-023-01424-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Focal breast edema and breast edema score on T2-weighted images provides valuable biological information for invasive breast cancer

Abstract

Background

Method

Results

Conclusions

Graphical Abstract

Critical relevance statement

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusions

Graphical Abstract

Critical relevance statement

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