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Radiation Oncology

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Open Access 01-12-2019 | Magnetic Resonance Imaging | Research

A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging

Authors: Ting Yu, Jian Bin Li, Wei Wang, Min Xu, Ying Jie Zhang, Qian Shao, Xi Jun Liu, Liang Xu

Published in: Radiation Oncology | Issue 1/2019

Abstract

Background

To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation imaging based on deformable image registration (DIR) for external-beam partial breast irradiation (EB-PBI) after breast-conserving surgery (BCS).

Methods

Eighteen breast cancer patients suitable for EB-PBI were enrolled. Preoperative prone diagnostic MRI and postoperative prone CT scan sets for all the patients were acquired during free breathing. Target volumes and ipsilateral breast were all contoured by the same radiation oncologist. The gross tumor volume (GTV) delineated on the preoperative MRI images was denoted as the GTV_preMR and the tumor bed (TB) delineated on the postoperative prone CT images was denoted as the GTV_postCT. The MIM software system was used to deformably register the MRI and CT images.

Results

When based on the coincidence of the compared target centers, there were statistically significant increases in the conformity index (CI) and degree of inclusion (DI) values for GTV_postCT-GTV_preMR, GTV_postCT-CTV_{preMR + 10}, CTV_{postCT + 10}-GTV_preMR, and CTV_{postCT + 10}-CTV_{preMR + 10} when compared with those based on the DIR of the thorax (Z = − 3.724, − 3.724, − 2.591, − 3.593, all P < 0.05; Z = -3.724, − 3.724, − 3.201, − 3.724, all P < 0.05, respectively).

Conclusions

Although based on DIR, there was relatively poor spatial overlap between the preoperative prone diagnostic MRI images and the postoperative prone CT simulation images for either the whole breast or the target volumes. Therefore, it is unreasonable to use preoperative prone diagnostic MRI images to guide postoperative target delineation for EB-PBI.

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Title: A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging
Authors: Ting Yu
Jian Bin Li
Wei Wang
Min Xu
Ying Jie Zhang
Qian Shao
Xi Jun Liu
Liang Xu
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Computed Tomography
Computed Tomography
Published in: Radiation Oncology / Issue 1/2019
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/s13014-019-1244-x

At a glance: The STEP trials

Springer Medicine

A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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