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Open Access 01-12-2013 | Review

Macrophages and angiogenesis in rheumatic diseases

Authors: Nicola Maruotti, Tiziana Annese, Francesco Paolo Cantatore, Domenico Ribatti

Published in: Vascular Cell | Issue 1/2013

Abstract

Angiogenesis plays a key role in several rheumatic diseases, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic sclerosis, systemic lupus erythematosus, and vasculitides. An imbalance between angiogenic inducers and inhibitors seems to be a critical factor in pathogenesis of these diseases. Macrophages promote angiogenesis during rheumatoid arthritis. In addition, macrophages can produce a variety of pro-angiogenic factors that have been associated with the angiogenic response occurring during other rheumatic diseases. Lastly, macrophages could be a target in the treatment of rheumatoid arthritis and other rheumatic diseases. Nevertheless, further studies are needed to better elucidate the exact role of macrophage in angiogenesis in these diseases.

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Title: Macrophages and angiogenesis in rheumatic diseases
Authors: Nicola Maruotti
Tiziana Annese
Francesco Paolo Cantatore
Domenico Ribatti
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Vascular Cell / Issue 1/2013
Electronic ISSN: 2045-824X
DOI: https://doi.org/10.1186/2045-824X-5-11

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