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01-05-2020 | Lymphoma | Commentary

Lymphoproliferations at extranodal sites: a morphologically, genetically, and clinically diverse group of neoplasms with overlapping features

Authors: John R. Goodlad, German Ott

Published in: Virchows Archiv | Issue 5/2020

Excerpt

The World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues represents a list of diseases regarded to be distinct entities, grouped together on the basis of shared morphology, immunophenotype, and genetic features. Clinical characteristics also make an important contribution when it comes to separating specific disease subgroups. For certain lymphomas, origin of disease, particularly at extranodal locations, is increasingly recognized as an important determinant of behavior and outcome. Extranodal presentation of lymphoma is common, with many cases encountered in the skin, stomach, small intestine, and brain, but virtually any organ can be involved [16]. They often represent a diagnostic challenge, encompassing a broad range of histological subtypes harboring a variety of molecular abnormalities and displaying a spectrum of clinical behaviors. Compared with nodal lymphomas displaying similar pathological features, they frequently display quite different outcomes and may present with specific organ-related problems, necessitating alternative approaches to management. …

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Title: Lymphoproliferations at extranodal sites: a morphologically, genetically, and clinically diverse group of neoplasms with overlapping features
Authors: John R. Goodlad
German Ott
Publication date: 01-05-2020
Publisher: Springer Berlin Heidelberg
Keyword: Lymphoma
Published in: Virchows Archiv / Issue 5/2020
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-019-02733-3

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Lymphoproliferations at extranodal sites: a morphologically, genetically, and clinically diverse group of neoplasms with overlapping features

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