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Skeletal Radiology
Published in: Skeletal Radiology 7/2020

01-07-2020 | Lymphoma | Case Report

Human T cell lymphotropic virus type-1 associated lymphoma presenting as an intramuscular mass of the calf

Authors: Natalia Gorelik, Syed T Hoda, Catherine Petchprapa, Cynthia Liu, Ronald Adler

Published in: Skeletal Radiology | Issue 7/2020

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Abstract

Adult T cell leukemia/lymphoma (ATLL) is a mature T cell neoplasm caused by the human oncogenic retrovirus human T lymphotropic virus type-1 (HTLV-1). While several musculoskeletal manifestations have been described in ATLL, skeletal muscle involvement is unusual, with only four cases reported in the English-language literature. We present a rare case of ATLL manifesting as an intra-muscular calf mass in a 58-year-old man who immigrated to the USA from West Africa. While skeletal muscle involvement by lymphoma is uncommon, it remains important to consider within the differential diagnosis when there are suggestive imaging findings because it entails important technical biopsy considerations as well as treatment implications. This case report also raises awareness of ATLL presenting outside of typical HTLV-1 endemic areas, related to current population migration patterns. ATLL should therefore be considered in patients with appropriate risk factors.
Literature
1.
Chun CW, Jee WH, Park HJ, Kim YJ, Park JM, Lee SH, et al. MRI features of skeletal muscle lymphoma. AJR Am J Roentgenol. 2010;195(6):1355–60.PubMed
2.
Komatsuda M, Nagao T, Arimori S. An autopsy case of malignant lymphoma associated with remarkable infiltration in skeletal muscles (author's transl). Rinsho Ketsueki. 1981;22(6):891–5.PubMed
3.
Suresh S, Saifuddin A, O'Donnell P. Lymphoma presenting as a musculoskeletal soft tissue mass: MRI findings in 24 cases. Eur Radiol. 2008;18(11):2628–34.PubMed
4.
Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol. 1995;164(1):129–34.PubMed
5.
Ohshima K, Jaffe E, Yoshino T, Siebert R. Adult T-cell Leukaemia/lymphoma. In: Swerdlow SHCE, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: International Agency for Research on Cancer; 2017. p. 363–7.
6.
Jean-Baptiste G, Smadja D, Arfi S. Manifestations neurologiques et rhumatologiques liées à l'infection par le virus HTLV-1. Rev Rhum. 2003;2(70):137–44.
7.
Caldwell CJ, Barrett WY, Breuer J, Farmer SF, Swash M. HTLV-1 polymyositis. Neuromuscul Disord. 1996;6(3):151–4.PubMed
8.
Saito M, Higuchi I, Saito A, Izumo S, Usuku K, Bangham CR, et al. Molecular analysis of T cell clonotypes in muscle-infiltrating lymphocytes from patients with human T lymphotropic virus type 1 polymyositis. J Infect Dis. 2002;186(9):1231–41.PubMed
9.
Gilbert DT, Morgan O, Smikle MF, Simeon D, Barton EN. HTLV-1 associated polymyositis in Jamaica. Acta Neurol Scand. 2001;104(2):101–4.PubMed
10.
Smadja D, Bellance R, Cabre P, Arfi S, Vernant JC. Clinical characteristics of HTLV-1 associated dermato-polymyositis. Seven cases from Martinique. Acta Neurol Scand. 1995;92(3):206–12.PubMed
11.
Ozden S, Cochet M, Mikol J, Teixeira A, Gessain A, Pique C. Direct evidence for a chronic CD8+-T-cell-mediated immune reaction to tax within the muscle of a human T-cell leukemia/lymphoma virus type 1-infected patient with sporadic inclusion body myositis. J Virol. 2004;78(19):10320–7.PubMedPubMedCentral
12.
Petscavage JM, Mulcahy H, Richardson ML. Human T-cell lymphotropic virus, type 1 (HTLV-1)-associated myelopathy: MR findings. Radiol Case Rep. 2011;6(2):416.PubMed
13.
Higuchi I, Hashimoto K, Kashio N, Izumo S, Matsuoka H, Nakagawa M, et al. In situ polymerase chain reaction detection of HTLV-I provirus and expression of the p53 tumor suppressor gene in infiltrating cells in skeletal muscle from a patient with adult T cell leukemia. Acta Neuropathol. 1995;90(3):323–7.PubMed
14.
Jo T, Shigematsu K. Extensive and destructive invasion of adult T-cell leukemia/lymphoma cells into systemic muscular tissues. Blood. 2014;124(10):1690.PubMedPubMedCentral
15.
Miyagi T, Nagasaki A, Taira T, Shinhama A, Suzuki M, Ohshima K, et al. Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature. Leuk Lymphoma. 2009;50(2):187–95.PubMed
16.
Furihata M, Ido E, Iwata J, Sonobe H, Ohtsuki Y, Takata J, et al. Adult T cell leukemia/lymphoma with massive involvement of cardiac muscle and valves. Pathol Int. 1998;48(3):221–4.PubMed
17.
18.
Levine PH, Dosik H, Joseph EM, Felton S, Bertoni MA, Cervantes J, et al. A study of adult T-cell leukemia/lymphoma incidence in Central Brooklyn. Int J Cancer. 1999;80(5):662–6.PubMed
19.
Martin F, Tagaya Y, Gallo R. Time to eradicate HTLV-1: an open letter to WHO. Lancet. 2018;391(10133):1893–4.PubMed
20.
Qayyum S, Choi JK. Adult T-cell leukemia/lymphoma. Arch Pathol Lab Med. 2014;138(2):282–6.PubMed
21.
22.
Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the lymphoma study group (1984-87). Br J Haematol. 1991;79(3):428–37.PubMed
23.
Phillips AA, Harewood JCK. Adult T cell leukemia-lymphoma (ATL): state of the art. Curr Hematol Malig Rep. 2018;13(4):300–7.PubMed
24.
Kitajima I, Yamamoto K, Sato K, Nakajima Y, Nakajima T, Maruyama I, et al. Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy. J Clin Invest. 1991;88(4):1315–22.PubMedPubMedCentral
25.
Kitajima I, Maruyama I, Maruyama Y, Ijichi S, Eiraku N, Mimura Y, et al. Polyarthritis in human T lymphotropic virus type I-associated myelopathy. Arthritis Rheum. 1989;32(10):1342–4.PubMed
26.
Guérin B, Arfi S, Numéric P, Jean-Baptiste G, Le Parc JM, Smadja D, et al. Polyarthritis in HTLV-1-infected patients. A review of 17 cases. Rev Rhum Engl Ed. 1995;62(1):21–8.PubMed
27.
Sato K, Maruyama I, Maruyama Y, Kitajima I, Nakajima Y, Higaki M, et al. Arthritis in patients infected with human T lymphotropic virus type I. clinical and immunopathologic features. Arthritis Rheum. 1991;34(6):714–21.PubMed
28.
Yancey WB, Dolson LH, Oblon D, Smith LJ, Braylan R, Longley S, et al. HTLV-I-associated adult T-cell leukemia/lymphoma presenting with nodular synovial masses. Am J Med. 1990;89(5):676–83.PubMed
29.
Nishioka K, Maruyama I, Sato K, Kitajima I, Nakajima Y, Osame M. Chronic inflammatory arthropathy associated with HTLV-I. Lancet. 1989;1(8635):441.PubMed
30.
Taniguchi A, Takenaka Y, Noda Y, Ueno Y, Shichikawa K, Sato K, et al. Adult t cell leukemia presenting with prolifeerative synovitis. Arthritis Rheum. 1988;31(8):1076–7.PubMed
31.
Harden EA, Moore JO, Haynes BF. Leukemia-associated arthritis: identification of leukemic cells in synovial fluid using monoclonal and polyclonal antibodies. Arthritis Rheum. 1984;27(11):1306–8.PubMed
32.
Yufu Y, Nonaka S, Nobunaga M. Adult T cell leukemia-lymphoma mimicking rheumatic disease. Arthritis Rheum. 1987;30(5):599–600.PubMed
33.
Austin CB, Young JW, Park HJ, Needleman BW, Handwerger BS, Rosenbaum RC. Massive acroosteolysis in adult T-cell leukemia/lymphoma. Radiology. 1987;164(3):787–9.PubMed
34.
Tannir N, Riggs S, Velasquez W, Samaan N, Manning J. Hypercalcemia, unusual bone lesions, and human T-cell leukemia-lymphoma virus in adult T-cell lymphoma. Cancer. 1985;55(3):615–9.PubMed
35.
Ehara S, Takahashi K, Nishida J, Uetani M, Ohashi K, Aoki T. Hand osteolysis in patients with adult T-cell leukemia-lymphoma: radiographic characteristics. Tohoku J Exp Med. 2015;236(1):63–9.PubMed
36.
Akinboyo IC, Crane GM, Chen L, Arav-Boger R. A 17-year-old boy with right face palsy, left leg weakness, and lytic skull-bone lesions. J Pediatric Infect Dis Soc. 2018;7(4):350–4.PubMedPubMedCentral
37.
Kessar P, Raftery MJ, Blakeney CG. Case report: multiple lytic lesions in HTLV1 associated ATLL in the absence of lymphadenopathy and peripheral blood changes. Clin Radiol. 1996;51(4):299–301.PubMed
38.
Hoque S, Kelsey S, van der Walt JD, Breuer J. Experience of human lymphotropic virus type I (HTLV-I) in an East London hospital. J Inf Secur. 1996;32(1):33–9.
39.
Beggs I. Primary muscle lymphoma. Clin Radiol. 1997;52(3):203–12.PubMed
40.
Surov A. Imaging findings of skeletal muscle lymphoma. Clin Imaging. 2014;38(5):594–8.PubMed
41.
Horwitz S, O’Connor OA, Pro B, Illidge T, Fanale M, Advani R, et al. Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial. Lancet. 2019;393(10168):229–40.PubMed
Metadata
Title
Human T cell lymphotropic virus type-1 associated lymphoma presenting as an intramuscular mass of the calf
Authors
Natalia Gorelik
Syed T Hoda
Catherine Petchprapa
Cynthia Liu
Ronald Adler
Publication date
01-07-2020
Publisher
Springer Berlin Heidelberg
Keywords
Lymphoma
Leukemia
Published in
Skeletal Radiology / Issue 7/2020
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-020-03392-1

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