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Diagnostic Pathology

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01-12-2021 | Lymphoma | Case Report

Monomorphic epitheliotropic intestinal T-cell lymphomas: a case report

Authors: Haibin Zhong, Yang Zheng, Feiran Zhang

Published in: Diagnostic Pathology | Issue 1/2021

Abstract

Background

Monomorphic epitheliotropic intestinal T-cell lymphomas (MEITL) is a rare and aggressive subtype of lymphoma. The most common site of origin is small intestine. Patients are often presented with diagnosis of intestinal perforation with abdominal pain as the main consulting symptoms. Because of the deficiency of specific diagnostic measures and effective management, diagnosis is often confirmed in advanced stage with poor prognosis.

Case presentation

Here, we introduce a patient who has suffered from abdominal pain and diarrhea, and eventually been diagnosed as Monomorphic epitheliotropic intestinal T-cell lymphomas.

Conclusion

MEITL is rare in clinical practice with deficiency of early diagnostic measures and poor prognosis. Therefore, any patient with ambiguous gastrointestinal symptoms or perforation of the digestive tract where the primary lesion is difficult to identify should be alert to the possibility of this disease.

van Vliet C, Spagnolo DV. T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update. Pathology. 2020;52(1):128–41. https://doi.org/10.1016/j.pathol.2019.10.001.CrossRefPubMed

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375–90. https://doi.org/10.1182/blood-2016-01-643569.CrossRefPubMedPubMedCentral

Tse E, Gill H, Loong F, Kim SJ, Ng SB, Tang T, et al. Type II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia lymphoma study group. Am J Hematol. 2012;87(7):663–8. https://doi.org/10.1002/ajh.23213.CrossRefPubMed

Delabie J, Holte H, Vose JM, Ullrich F, Jaffe ES, Savage KJ, et al. Enteropathy-associated T-cell lymphoma: clinical and histological findings from the international peripheral T-cell lymphoma project. Blood. 2011;118(1):148–55. https://doi.org/10.1182/blood-2011-02-335216.CrossRefPubMed

Mugnaini EN, Ghosh N. Lymphoma. Prim Care. 2016;43(4):661–75. https://doi.org/10.1016/j.pop.2016.07.012.CrossRefPubMed

Antoniadou F, Dimitrakopoulou A, Voutsinas PM, Vrettou K, Vlahadami I, Voulgarelis M, et al. Monomorphic epitheliotropic intestinal T-cell lymphoma in pleural effusion: a case report. Diagn Cytopathol. 2017;45(11):1050–4. https://doi.org/10.1002/dc.23772.CrossRefPubMed

Lenti MV, Biagi F, Lucioni M, di Sabatino A, Paulli M, Corazza GR. Two cases of monomorphic epitheliotropic intestinal T-cell lymphoma associated with coeliac disease. Scand J Gastroenterol. 2019;54(8):965–8. https://doi.org/10.1080/00365521.2019.1647455.CrossRefPubMed

Tan SY, Chuang SS, Tang T, Tan L, Ko YH, Chuah KL, et al. Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8alphaalpha phenotype. Leukemia. 2013;27(8):1688–96. https://doi.org/10.1038/leu.2013.41.CrossRefPubMed

Soardo G, Castaldo V, Donnini D, Uzzau A, Pizzolitto S, Sechi LA. Monomorphic Epitheliotropic intestinal T cell lymphoma of the appendix: a case report and review of literature. J Gastrointest Cancer. 2020;51(2):688–94. https://doi.org/10.1007/s12029-020-00363-6.CrossRefPubMed

10.

Yi JH, Lee GW, Do YR, Jung HR, Hong JY, Yoon DH, et al. Multicenter retrospective analysis of the clinicopathologic features of monomorphic epitheliotropic intestinal T-cell lymphoma. Ann Hematol. 2019;98(11):2541–50. https://doi.org/10.1007/s00277-019-03791-y.CrossRefPubMed

Title: Monomorphic epitheliotropic intestinal T-cell lymphomas: a case report
Authors: Haibin Zhong
Yang Zheng
Feiran Zhang
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Lymphoma
Celiac Disease
Celiac Disease
Key Symptom
Abdominal Pain
Published in: Diagnostic Pathology / Issue 1/2021
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-021-01143-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Monomorphic epitheliotropic intestinal T-cell lymphomas: a case report

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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