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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2004

01-09-2004 | Poster presentation

Interferon-induced gene expression in systemic lupus erythematosus reflects previous exposure to interferon alpha and is associated with increased disease activity and autoreactivity against RNA-binding proteins

Authors: KA Kirou, CY Lee, SS George, MK Crow

Published in: Arthritis Research & Therapy | Special Issue 3/2004

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Excerpt

Both interferon (IFN) alpha and IFN-γ have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Recently, microarray screens have demonstrated increased IFN-inducible gene (IFIG) expression in peripheral blood mononuclear cells of patients with active SLE. We investigated the relative roles of IFN-α and IFN-γ in gene expression and disease in SLE patients. …
Metadata
Title
Interferon-induced gene expression in systemic lupus erythematosus reflects previous exposure to interferon alpha and is associated with increased disease activity and autoreactivity against RNA-binding proteins
Authors
KA Kirou
CY Lee
SS George
MK Crow
Publication date
01-09-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 3/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1406

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